Review
doi: 10.1089/lrb.2013.0012.
Epub 2013 Sep 11.
Lymphatic function and immune regulation in health and disease
Affiliations
- PMID: 24024577
- PMCID: PMC3780287
- DOI: 10.1089/lrb.2013.0012
Item in Clipboard
Review
Lymphatic function and immune regulation in health and disease
Lymphat Res Biol.
.
Free PMC article
No abstract available
Figures
Alterations to the lymphatic system in pathological conditions. (A) The normal lymphatic system consists of lymphatic capillaries that form lymph, collecting lymphatic vessels that transport lymph, and lymph nodes that organize immune responses. Each of these structures has its own unique microarchitecture that contributes to the maintenance of proper immune function. (B) During inflammation, lymphangiogenesis is seen in the lymphatic capillaries as well as in the local draining lymph node. Furthermore, a robust infiltrate of myeloid-derived cells accumulate around the collecting lymphatic vessels, which is correlated with suppression of lymphatic contractions and weakened immune response. (C) During tumor growth, lymphangiogenesis is also seen in the tumor periphery and surrounding tissue. Furthermore, robust lymphangiogenesis has been observed in the lymph node, along with architectural changes associated with creating an environment receptive to tumor metastases. The ability of tumors to alter collecting lymphatic vessel contraction is not known. (D) Little is known about the response of lymphatic vessels to microorganisms or viral infections. However, there is a strong clinical link between infectious disease and lymphedema. This area needs much greater scrutiny to identify new opportunities to treat infections that are difficult to clear.
Similar articles
-
The Lymphatic System in Disease Processes and Cancer Progression.Annu Rev Biomed Eng. 2016 Jul 11;18:125-58. doi: 10.1146/annurev-bioeng-112315-031200. Epub 2016 Feb 5. Annu Rev Biomed Eng. 2016. PMID: 26863922 Free PMC article. Review.
-
The lymphatic vasculature in disease.Nat Med. 2011 Nov 7;17(11):1371-80. doi: 10.1038/nm.2545. Nat Med. 2011. PMID: 22064427 Review.
-
[Normal and diseased lymphatics of lungs and pleura].Rev Pneumol Clin. 2013 Apr;69(2):61-2. doi: 10.1016/j.pneumo.2012.12.004. Epub 2013 Mar 19. Rev Pneumol Clin. 2013. PMID: 23523229 French. No abstract available.
-
The lymphatic system in health and disease.Lymphat Res Biol. 2008;6(3-4):109-22. doi: 10.1089/lrb.2008.1008. Lymphat Res Biol. 2008. PMID: 19093783 Free PMC article. Review.
-
Lymphatic Changes in Respiratory Diseases: More than Just Remodeling of the Lung?Am J Respir Cell Mol Biol. 2017 Sep;57(3):272-279. doi: 10.1165/rcmb.2016-0290TR. Am J Respir Cell Mol Biol. 2017. PMID: 28443685 Free PMC article. Review.
Cited by 16 articles
-
Microenvironment-Dependent Gradient of CTL Exhaustion in the AE17sOVA Murine Mesothelioma Tumor Model.Front Immunol. 2020 Jan 10;10:3074. doi: 10.3389/fimmu.2019.03074. eCollection 2019. Front Immunol. 2020. PMID: 31998326 Free PMC article.
-
Application of microscale culture technologies for studying lymphatic vessel biology.Microcirculation. 2019 Nov;26(8):e12547. doi: 10.1111/micc.12547. Epub 2019 May 2. Microcirculation. 2019. PMID: 30946511 Review.
-
Cisterna Magna Injection in Rats to Study Glymphatic Function.Methods Mol Biol. 2019;1938:97-104. doi: 10.1007/978-1-4939-9068-9_7. Methods Mol Biol. 2019. PMID: 30617975 Free PMC article.
-
Lymphatic Tissue Engineering and Regeneration.J Biol Eng. 2018 Dec 17;12:32. doi: 10.1186/s13036-018-0122-7. eCollection 2018. J Biol Eng. 2018. PMID: 30564284 Free PMC article. Review.
-
Inducible Nitric Oxide Synthase and CD11b+Gr1+ Cells Impair Lymphatic Contraction of Tumor-Draining Lymphatic Vessels.Lymphat Res Biol. 2019 Jun;17(3):294-300. doi: 10.1089/lrb.2018.0013. Epub 2018 Oct 24. Lymphat Res Biol. 2019. PMID: 30358484 Free PMC article.
Publication types
MeSH terms
Grant support
LinkOut - more resources
-
Full Text Sources
-
Other Literature Sources
-
Medical
