Clinical Research Trials

About Clinical Research at TMC HealthCare

TMC HealthCare conducts a variety of high-level clinical research trials in an efficient and safe manner in order to improve the well-being and lives for all patients. We are dedicated to taking all the steps necessary to bring quality care through research and giving back to the community for a better health care system. We are committed to honesty; we value our resources; and we implement our values into all the studies we conduct. All research conducted at TMC is dedicated to improving and modernizing the medical industry, providing more efficient and safer treatments worldwide, showing broad and diverse research, and taking a step forward for a better health and future for the community.

Understanding Clinical Research

Clinical research helps doctors learn new ways to prevent and treat diseases, and find answers to questions about health, disease entity and human behavior. Clinical research leads to the development of new drugs, less-invasive measures of treatment compared with the standard, and new ways to prevent disease in people at high risk. Research also connects our community to leading-edge therapies. Clinical research may include studies for:

  • New drugs or new combinations of drugs
  • New surgical and less-invasive procedures
  • New medical devices
  • New ways to use existing treatments
  • How to change behaviors to improve health
  • New methods to detect diseases and health conditions
  • New ways to improve quality of life for people with serious health conditions

The Critical Role of Volunteers

Many of our medical advances occurred because people volunteered to participate in clinical trials and other types of clinical research. People choose to participate in clinical research and trials because they want to take part in the advancement of new discoveries, because they feel empowered when they take a more active role in their health, or because they can gain access to new therapies before they are widely available. Volunteers include healthy individuals from surrounding communities as well as people with known health problems.

There are generally four different study types that may be offered at TMC HealthCare:

  • Phase I: A small group of healthy individuals who test the safety, dosage and side effects of novel and experimental treatments. These trials will usually last three to four months.
  • Phase II: Tests a treatment’s efficacy by randomizing the treatment against a placebo or control group.
  • Phase III: Determines the long-term effects of the treatment on a larger group, often spanning a few years. This stage is generally where drugs will have enough data to gain FDA approval
  • Phase IV: Occurs after the experimental treatment has been approved by the FDA, but the treatment is being tested further to gather more information on the treatment.

Clinical research conducted at TMC HealthCare is approved by the Institutional Review Board, or IRB. The IRB is a government-mandated agency that is required by federal law to review and approve all clinical trials involving human subjects. TMC HealthCare strictly follows IRB guidelines to ensure patient safety and health.

Clinical Trials at TMC HealthCare


AMPLATZER PFO: Occluder Post Approval Study

What is the Purpose of this Study? To prevent recurrent ischemic stroke with the AMPLATZER PFO occluder device

Principal investigator: Dr. Thomas Waggoner

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PROTECTED TAVR: Stroke Protection with Sentinel During Transcatheter Aortic Valve Replacement

What is the purpose of this study? To reduce the risk of a peri-procedural stroke after a trancather aortic vale replacement.

Principal investigator: Dr. Thomas Waggoner

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REPRISE IV: Repositionable Percutaneous Replacement of Stenotic Aortic Valve through Implantation of LOTUS Edge Valve System in Intermediate Surgical Risk Subjects

What is the purpose of this study? To evaluate the Lotus Edge to treat patients with aortic stenosis.

Principal investigator: Dr. Thomas Waggoner

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Supra-Annular vs. Annular ValvEs for Small Annuli (≤ 23 mm) (S.A.V.E.)

What is the purpose of this study? To reduce risk of prosthesis-patient mismatch rates in patients with a small annuli.

Principal investigator: Dr. Neil Gheewala

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Expanded Access to Convalescent Plasma for the Treatment of Patients with COVID-19

What is the purpose of this study? To provide access to investigational convalescent plasma for patients with high risk of progression to severe COVID-19.

Site lead physicians: Drs. Ives de Chazal and Laura Valdivia

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Investigation of Antibody and Immune Responses to Severe Acute Syndrome Coronavirus 2 (SARS-CoV-2) in COVID-19 Patients

What is the purpose of this study? To evaluate the exposure, immunity, diagnosis, and prognosis of SARS-CoV-2 infections.

Principal investigator: Dr. Katehrine Scott

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Treating COVID-19 with a Bidirectional Oxygenation Valve

What is the purpose of this study? To evaluate the if the use of a bidirectional oxygenation mouthpiece with conventional oxygen support enhances respiratory function in any Person Under Investigation for infection by the COVID-19 virus.

Principal investigator: Dr. Matthew Weiner

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TrialNet Pathway to Prevention of Type 1 Diabetes

What is the purpose of this study? To study prevention and early treatment of type 1 diabetes.

Principal investigator: Dr. Chetanbabu Patel

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More Clinical Trial Directories

You can also find clinical trials at TMC HealthCare through Use this searchable database of publicly- and privately-supported clinical studies conducted at TMC HealthCare and around the world. 

Contact Us

Clinical Research
Office: (520) 324-5512