Curcumin analogues with high activity for inhibiting human prostate cancer cell growth and androgen receptor activation
- PMID: 25060817
- DOI: 10.3892/mmr.2014.2380
Curcumin analogues with high activity for inhibiting human prostate cancer cell growth and androgen receptor activation
Abstract
The androgen receptor (AR) has a critical role in prostate cancer development and progression. Several curcumin analogues (A10, B10, C10, E10 and F10) with different linker groups were investigated for their effects in human prostate cancer CWR‑22Rv1 and LNCaP cell lines. The ability of these compounds to inhibit testosterone (TT)‑ or dihydrotestosterone (DHT)‑induced AR activity was determined by an AR‑linked luciferase assay and by TT‑ or DHT‑induced expression of prostate specific antigen. Compounds F10 and E10 had stronger inhibitory effects on the growth of cultured CWR‑22Rv1 and LNCaP cell lines, and they also had enhanced stimulatory effects on apoptosis compared with curcumin and other curcumin analogues (A10, B10, C10) in CWR‑22Rv1 cells. E10 and F10 were more potent inhibitors of AR activity than curcumin, A10 and B10. The higher activities of E10 and F10 may be correlated with a heteroatom linker. The results indicate that one of the potential mechanisms for the anticancer effect of the curcumin analogues was inhibition of AR pathways in human prostate cancer cells.
Similar articles
-
[Inhibition of the expression of prostate specific antigen by curcumin].Yao Xue Xue Bao. 2005 Sep;40(9):800-3. Yao Xue Xue Bao. 2005. PMID: 16342680 Chinese.
-
TGF-beta signaling and androgen receptor status determine apoptotic cross-talk in human prostate cancer cells.Prostate. 2008 Feb 15;68(3):287-95. doi: 10.1002/pros.20698. Prostate. 2008. PMID: 18163430
-
A novel synthetic compound that interrupts androgen receptor signaling in human prostate cancer cells.Mol Cancer Ther. 2007 Jul;6(7):2057-64. doi: 10.1158/1535-7163.MCT-06-0735. Mol Cancer Ther. 2007. PMID: 17620434
-
Novel anti-prostate cancer curcumin analogues that enhance androgen receptor degradation activity.Anticancer Agents Med Chem. 2009 Oct;9(8):904-12. doi: 10.2174/187152009789124655. Anticancer Agents Med Chem. 2009. PMID: 19663790 Review.
-
Molecular mechanisms of curcumin and its semisynthetic analogues in prostate cancer prevention and treatment.Life Sci. 2016 May 1;152:135-44. doi: 10.1016/j.lfs.2016.03.036. Epub 2016 Mar 24. Life Sci. 2016. PMID: 27018446 Free PMC article. Review.
Cited by 13 articles
-
Curcumin, a Multifaceted Hormetic Agent, Mediates an Intricate Crosstalk between Mitochondrial Turnover, Autophagy, and Apoptosis.Oxid Med Cell Longev. 2020 Jul 18;2020:3656419. doi: 10.1155/2020/3656419. eCollection 2020. Oxid Med Cell Longev. 2020. PMID: 32765806 Free PMC article. Review.
-
Therapies Targeted to Androgen Receptor Signaling Axis in Prostate Cancer: Progress, Challenges, and Hope.Cancers (Basel). 2019 Dec 23;12(1):51. doi: 10.3390/cancers12010051. Cancers (Basel). 2019. PMID: 31877956 Free PMC article. Review.
-
Structure-Based Classification and Anti-Cancer Effects of Plant Metabolites.Int J Mol Sci. 2018 Sep 6;19(9):2651. doi: 10.3390/ijms19092651. Int J Mol Sci. 2018. PMID: 30200668 Free PMC article. Review.
-
The Curcumin Analogs 2-Pyridyl Cyclohexanone Induce Apoptosis via Inhibition of the JAK2-STAT3 Pathway in Human Esophageal Squamous Cell Carcinoma Cells.Front Pharmacol. 2018 Aug 21;9:820. doi: 10.3389/fphar.2018.00820. eCollection 2018. Front Pharmacol. 2018. PMID: 30186159 Free PMC article.
-
Curcumin Derivative Epigenetically Reactivates Nrf2 Antioxidative Stress Signaling in Mouse Prostate Cancer TRAMP C1 Cells.Chem Res Toxicol. 2018 Feb 19;31(2):88-96. doi: 10.1021/acs.chemrestox.7b00248. Epub 2018 Jan 8. Chem Res Toxicol. 2018. PMID: 29228771 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
-
Full Text Sources
-
Other Literature Sources
-
Medical
-
Research Materials
-
Miscellaneous