Review
doi: 10.1146/annurev.nutr.17.1.305.
The cholesterol-raising factor from coffee beans
Affiliations
- PMID: 9240930
- DOI: 10.1146/annurev.nutr.17.1.305
Item in Clipboard
Review
The cholesterol-raising factor from coffee beans
Annu Rev Nutr.
.
Abstract
Some coffee brewing techniques raise the serum concentration of total and low-density-lipoprotein cholesterol in humans, whereas others do not. The responsible factors are the diterpene lipids cafestol and kahweol, which make up about 1% (wt:wt) of coffee beans. Diterpenes are extracted by hot water but are retained by a paper filter. This explains why filtered coffee does not affect cholesterol, whereas Scandinavian "boiled," cafetiere, and Turkish coffees do. We describe the identification of the cholesterol-raising factors, their effects on blood levels of lipids and liver function enzymes, and their impact on public health, based on papers published up to December 1996.
Similar articles
-
The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors.Mol Endocrinol. 2007 Jul;21(7):1603-16. doi: 10.1210/me.2007-0133. Epub 2007 Apr 24. Mol Endocrinol. 2007. PMID: 17456796
-
The cholesterol-raising factor from coffee beans.J R Soc Med. 1996 Nov;89(11):618-23. J R Soc Med. 1996. PMID: 9135590 Free PMC article. Review.
-
Cholesterol-raising diterpenes in types of coffee commonly consumed in Singapore, Indonesia and India and associations with blood lipids: a survey and cross sectional study.Nutr J. 2011 May 15;10:48. doi: 10.1186/1475-2891-10-48. Nutr J. 2011. PMID: 21569629 Free PMC article.
-
Identity of the cholesterol-raising factor from boiled coffee and its effects on liver function enzymes.J Lipid Res. 1994 Apr;35:721-33. J Lipid Res. 1994. PMID: 7911820 Clinical Trial.
-
Validity of animal models for the cholesterol-raising effects of coffee diterpenes in human subjects.Proc Nutr Soc. 1999 Aug;58(3):551-7. doi: 10.1017/s0029665199000725. Proc Nutr Soc. 1999. PMID: 10604186 Review.
Cited by 23 articles
-
Association between coffee consumption and risk of bladder cancer in a meta-analysis of 16 prospective studies.Nutr Metab (Lond). 2019 Sep 13;16:66. doi: 10.1186/s12986-019-0390-3. eCollection 2019. Nutr Metab (Lond). 2019. PMID: 31528185 Free PMC article.
-
Cafestol and Kahweol: A Review on Their Bioactivities and Pharmacological Properties.Int J Mol Sci. 2019 Aug 30;20(17):4238. doi: 10.3390/ijms20174238. Int J Mol Sci. 2019. PMID: 31480213 Free PMC article. Review.
-
Prospective associations between beverage intake during the midlife and subclinical carotid atherosclerosis: The Study of Women's Health Across the Nation.PLoS One. 2019 Jul 10;14(7):e0219301. doi: 10.1371/journal.pone.0219301. eCollection 2019. PLoS One. 2019. PMID: 31291324 Free PMC article.
-
Consumption of decaffeinated coffee protects against the development of early non-alcoholic steatohepatitis: Role of intestinal barrier function.Redox Biol. 2019 Feb;21:101092. doi: 10.1016/j.redox.2018.101092. Epub 2018 Dec 23. Redox Biol. 2019. PMID: 30605883 Free PMC article.
-
Coffee consumption and risk of rare cancers in Scandinavian countries.Eur J Epidemiol. 2018 Mar;33(3):287-302. doi: 10.1007/s10654-018-0369-9. Epub 2018 Feb 23. Eur J Epidemiol. 2018. PMID: 29476356
Publication types
MeSH terms
Substances
LinkOut - more resources
-
Full Text Sources
-
Other Literature Sources
-
Medical