doi: 10.1126/science.8346443.
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
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- PMID: 8346443
- DOI: 10.1126/science.8346443
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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
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Abstract
The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-epsilon 4 alleles in 42 families with late onset AD. Thus APOE-epsilon 4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-epsilon 4 was virtually sufficient to cause AD by age 80.
Comment in
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New piece in Alzheimer's puzzle.Science. 1993 Aug 13;261(5123):828-9. doi: 10.1126/science.8346434. Science. 1993. PMID: 8346434 No abstract available.
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