Caffeine intake (200 mg) in the morning affects human sleep and EEG power spectra at night
- PMID: 7796154
- DOI: 10.1016/0006-8993(95)00040-w
Caffeine intake (200 mg) in the morning affects human sleep and EEG power spectra at night
Abstract
Adenosine has been implicated in the physiological regulation of sleep propensity. The adenosine-receptor-antagonist, caffeine (100 mg), administered immediately prior to a nocturnal sleep episode, has previously been shown to lower sleep propensity as indexed by a reduced sleep efficiency, a reduced EEG power density in low delta frequencies and enhanced power density in the frequency range of sleep spindles. To further investigate the role of adenosine in sleep regulation we administered 200 mg of caffeine at 07.10 h and analyzed the sleep stages and EEG power spectra during the subsequent night in nine healthy men. Caffeine levels in saliva decreased from a maximum of 17 mumol/l one hour after intake, to 3 mumol/l immediately prior to the sleep episode starting at 23.00 h. Compared to placebo, sleep efficiency and total sleep time were significantly reduced. EEG power density in nonREM sleep was suppressed in the 0.25-0.5 Hz band and enhanced in the frequency range of sleep spindles (11.25-12.0 Hz and 13.25-14.0 Hz). In REM sleep EEG power density was suppressed in the frequency range of 0.75-4.5 and 5.25-6.0 Hz. The data indicate that a saliva level of caffeine as low as 3 mumol/l directly affects sleep propensity or, alternatively, that the presence of caffeine in the central nervous system during the waking episode reduces the progressive increase of sleep propensity associated with wakefulness.
Similar articles
-
Caffeine attenuates waking and sleep electroencephalographic markers of sleep homeostasis in humans.Neuropsychopharmacology. 2004 Oct;29(10):1933-9. doi: 10.1038/sj.npp.1300526. Neuropsychopharmacology. 2004. PMID: 15257305 Clinical Trial.
-
Late-afternoon ethanol intake affects nocturnal sleep and the sleep EEG in middle-aged men.J Clin Psychopharmacol. 1996 Dec;16(6):428-36. doi: 10.1097/00004714-199612000-00004. J Clin Psychopharmacol. 1996. PMID: 8959467 Clinical Trial.
-
Caffeine reduces low-frequency delta activity in the human sleep EEG.Neuropsychopharmacology. 1995 May;12(3):229-38. doi: 10.1016/0893-133X(94)00079-F. Neuropsychopharmacology. 1995. PMID: 7612156
-
Sleep homeostasis: a role for adenosine in humans?Biochem Pharmacol. 2008 Jun 1;75(11):2070-9. doi: 10.1016/j.bcp.2008.02.024. Epub 2008 Mar 4. Biochem Pharmacol. 2008. PMID: 18384754 Review.
-
The visual scoring of sleep and arousal in infants and children.J Clin Sleep Med. 2007 Mar 15;3(2):201-40. J Clin Sleep Med. 2007. PMID: 17557427 Review.
Cited by 32 articles
-
Motivations Influencing Caffeine Consumption Behaviors among College Students in Korea: Associations with Sleep Quality.Nutrients. 2020 Mar 30;12(4):953. doi: 10.3390/nu12040953. Nutrients. 2020. PMID: 32235502 Free PMC article.
-
Electrophysiological characterization of sleep/wake, activity and the response to caffeine in adult cynomolgus macaques.Neurobiol Sleep Circadian Rhythms. 2018 Aug 22;6:9-23. doi: 10.1016/j.nbscr.2018.08.001. eCollection 2019 Jan. Neurobiol Sleep Circadian Rhythms. 2018. PMID: 31236518 Free PMC article.
-
Sport Nutrigenomics: Personalized Nutrition for Athletic Performance.Front Nutr. 2019 Feb 19;6:8. doi: 10.3389/fnut.2019.00008. eCollection 2019. Front Nutr. 2019. PMID: 30838211 Free PMC article. Review.
-
Effects of caffeine on sleep quality and daytime functioning.Risk Manag Healthc Policy. 2018 Dec 7;11:263-271. doi: 10.2147/RMHP.S156404. eCollection 2018. Risk Manag Healthc Policy. 2018. PMID: 30573997 Free PMC article. Review.
-
Effects of chronic caffeine consumption on sleep and the sleep electroencephalogram in mice.J Psychopharmacol. 2019 Jan;33(1):122-131. doi: 10.1177/0269881118806300. Epub 2018 Oct 24. J Psychopharmacol. 2019. PMID: 30354930 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
-
Full Text Sources
-
Other Literature Sources
-
Medical
