Renal and cardiovascular effects of caffeine: a dose-response study
- PMID: 3297472
- DOI: 10.1042/cs0720749
Renal and cardiovascular effects of caffeine: a dose-response study
Abstract
The effects of increasing oral doses of caffeine (45, 90, 180 and 360 mg) on effective renal plasma flow (ERPF), plasma renin activity (PRA), serum electrolytes, plasma noradrenaline, blood pressure and heart rate were studied in eight healthy male volunteers. Urine volume was increased by 360 mg of caffeine only. At caffeine doses greater than 90 mg urinary sodium excretion was significantly increased. There were no changes in ERPF. Serum potassium was significantly reduced by 360 mg of caffeine. Caffeine increased systolic pressure in a dose related manner. Diastolic pressure was also increased, but not in relation to dose. A 360 mg dose of caffeine produced a late increase in heart rate. These changes were not associated with any alterations in PRA or in plasma noradrenaline.
Similar articles
-
The effects of intravenous L-dopa on plasma renin activity, renal function, and blood pressure in man.Eur J Clin Pharmacol. 1988;35(2):137-41. doi: 10.1007/BF00609242. Eur J Clin Pharmacol. 1988. PMID: 3056728
-
Effects of caffeine on plasma renin activity, catecholamines and blood pressure.N Engl J Med. 1978 Jan 26;298(4):181-6. doi: 10.1056/NEJM197801262980403. N Engl J Med. 1978. PMID: 339084 Clinical Trial.
-
Caffeine attenuates the renal vascular response to angiotensin II infusion.Hypertension. 1993 Dec;22(6):847-52. doi: 10.1161/01.hyp.22.6.847. Hypertension. 1993. PMID: 8244516
-
Effects of iloprost, a prostacyclin analog derivative, on renal plasma flow, renal function, and renin-aldosterone system in humans.Clin Pharmacol Ther. 1988 Aug;44(2):211-6. doi: 10.1038/clpt.1988.139. Clin Pharmacol Ther. 1988. PMID: 2456174 Clinical Trial.
-
Effects of dopamine on renal haemodynamics tubular function and sodium excretion in normal humans.Dan Med Bull. 1998 Jun;45(3):282-97. Dan Med Bull. 1998. PMID: 9675540 Review.
Cited by 24 articles
-
The Effect of Coffee on Pharmacokinetic Properties of Drugs : A Review.Biomed Res Int. 2020 Jul 24;2020:7909703. doi: 10.1155/2020/7909703. eCollection 2020. Biomed Res Int. 2020. PMID: 32775441 Free PMC article. Review.
-
High-fructose corn syrup-sweetened soft drink consumption increases vascular resistance in the kidneys at rest and during sympathetic activation.Am J Physiol Renal Physiol. 2020 Apr 1;318(4):F1053-F1065. doi: 10.1152/ajprenal.00374.2019. Epub 2020 Mar 16. Am J Physiol Renal Physiol. 2020. PMID: 32174139
-
The Influence of Caffeine Supplementation on Resistance Exercise: A Review.Sports Med. 2019 Jan;49(1):17-30. doi: 10.1007/s40279-018-0997-y. Sports Med. 2019. PMID: 30298476 Review.
-
Influence of acute consumption of caffeine vs. placebo over Bia-derived measurements of body composition: a randomized, double-blind, crossover design.J Int Soc Sports Nutr. 2018 Feb 13;15:7. doi: 10.1186/s12970-018-0211-5. eCollection 2018. J Int Soc Sports Nutr. 2018. PMID: 29449791 Free PMC article. Clinical Trial.
-
Coffee consumption and risk of hypertension: a dose-response meta-analysis of prospective studies.Eur J Nutr. 2019 Feb;58(1):271-280. doi: 10.1007/s00394-017-1591-z. Epub 2017 Dec 8. Eur J Nutr. 2019. PMID: 29222637
Publication types
MeSH terms
Substances
LinkOut - more resources
-
Full Text Sources
-
Other Literature Sources
-
Medical
-
Research Materials
-
Miscellaneous