Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice
- PMID: 3180222
- DOI: 10.1016/0092-8674(88)90220-6
Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice
Abstract
Transcriptional activation of the int-1 gene by proviral insertion mutations is thought to be a key step in mammary tumor induction by the mouse mammary tumor virus (MMTV). To test this hypothesis, we have constructed an int-1 allele resembling those found in virus-induced tumors, with an MMTV LTR placed 5' to the int-1 gene in the opposite transcriptional orientation. Transgenic mice harboring this allele express int-1 RNA at high levels in mammary and salivary glands of male and female mice and in male reproductive organs. The mammary glands of males and virgin females are grossly hyperplastic compared with those of nontrasgenic littermates. Mammary and (less frequently) salivary adenocarcinomas occur in these animals at rates indicating that transcriptional activation of int-1 and associated hyperplasia are initiating events in multistep carcinogenesis.
Similar articles
-
Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands.Genes Dev. 1992 Mar;6(3):345-55. doi: 10.1101/gad.6.3.345. Genes Dev. 1992. PMID: 1372276
-
Synergistic interaction of transforming growth factor alpha and c-myc in mouse mammary and salivary gland tumorigenesis.Cell Growth Differ. 1995 Jun;6(6):737-48. Cell Growth Differ. 1995. PMID: 7669729
-
MMTV-Fgf8 transgenic mice develop mammary and salivary gland neoplasia and ovarian stromal hyperplasia.Oncogene. 1998 Nov 26;17(21):2711-7. doi: 10.1038/sj.onc.1202212. Oncogene. 1998. PMID: 9840935
-
Keratinocyte growth factor induces mammary and prostatic hyperplasia and mammary adenocarcinoma in transgenic mice.Oncogene. 1996 Dec 19;13(12):2507-15. Oncogene. 1996. PMID: 9000125
-
Transgenic mice and host cell mutants resistant to transformation as model systems for identifying multiple components in oncogenesis.Ciba Found Symp. 1989;142:20-6; discussion 26-35. doi: 10.1002/9780470513750.ch3. Ciba Found Symp. 1989. PMID: 2545421 Review.
Cited by 269 articles
-
FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors.Breast Cancer Res. 2020 Jun 3;22(1):59. doi: 10.1186/s13058-020-01298-3. Breast Cancer Res. 2020. PMID: 32493400 Free PMC article.
-
The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche.Nat Commun. 2020 Mar 26;11(1):1571. doi: 10.1038/s41467-020-15357-y. Nat Commun. 2020. PMID: 32218432 Free PMC article.
-
Fetal Alcohol Exposure Alters Mammary Epithelial Cell Subpopulations and Promotes Tumorigenesis.Alcohol Clin Exp Res. 2020 Apr;44(4):831-843. doi: 10.1111/acer.14308. Epub 2020 Mar 4. Alcohol Clin Exp Res. 2020. PMID: 32056248
-
Cancer cell-intrinsic function of CD177 in attenuating β-catenin signaling.Oncogene. 2020 Apr;39(14):2877-2889. doi: 10.1038/s41388-020-1203-x. Epub 2020 Feb 10. Oncogene. 2020. PMID: 32042113 Free PMC article.
-
Complex Interplay between the RUNX Transcription Factors and Wnt/β-Catenin Pathway in Cancer: A Tango in the Night.Mol Cells. 2020 Feb 29;43(2):188-197. doi: 10.14348/molcells.2019.0310. Mol Cells. 2020. PMID: 32041394 Free PMC article. Review.
Publication types
MeSH terms
Grant support
LinkOut - more resources
-
Full Text Sources
-
Other Literature Sources
-
Medical
-
Molecular Biology Databases