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Clinical Trial
. 2015 Apr 30;7(5):3138-53.
doi: 10.3390/nu7053138.

Consumption of a polyphenol-rich grape-wine extract lowers ambulatory blood pressure in mildly hypertensive subjects

Richard Draijer  1 , Young de Graaf  2 , Marieke Slettenaar  3 , Eric de Groot  4 , Chris I Wright  5
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Clinical Trial

Consumption of a polyphenol-rich grape-wine extract lowers ambulatory blood pressure in mildly hypertensive subjects

Richard Draijer et al. Nutrients. .
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Abstract

Polyphenols in grape and wine have been suggested to contribute to the cardiovascular health benefits of the Mediterranean lifestyle. The reported effects of grape products on blood pressure (BP) remain, however, equivocal. In a double-blind placebo controlled crossover study, the effect of two grape extracts on BP and vascular function was assessed in 60 untreated, mildly hypertensive subjects after four weeks intervention. Both extracts (grape-red wine and grape alone) had high concentrations of anthocyanins and flavonols, but the grape alone was relatively poor in catechins and procyanidins. Parameters measured included ambulatory and office BP, flow-mediated vasodilation, arterial distensibility, platelet function and plasma lipoproteins. Results showed that 24-hour ambulatory systolic/diastolic BPs were significantly lower in the grape-wine extract intervention (135.9 ± 1.3/84.7 ± 0.8 mmHg; mean ± SEM) compared to placebo (138.9 ± 1.3/86.6 ± 1.2 mmHg), predominantly during daytime. Plasma concentrations of the vasoconstrictor endothelin-1 decreased by 10%, but other measures of vascular function were not affected. Grape juice extract alone had no effect on BP or any measures of vascular function. Polyphenol-rich food products, and may be specifically catechins and procyanidins, may thus help sustain a healthy BP and contribute to the healthy Mediterranean lifestyle.

Figures

Figure 1
Twenty-four-hour ambulatory recordings of SBP and DBP. This data was extracted from intervention group 1 where placebo was compared with the grape-wine extract. Mean data per time point from 30 subjects is presented. The red line represents placebo and the blue line the grape-wine extract. Circles represent SBP and triangles DBP. Time zero started at 1:00 p.m. and ended at 1:00 p.m. on the following day. Compared to placebo, SBP and DBP were lower during the daytime with the grape-wine extract, but the extract did not affect the nighttime BP change.
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