A new look at cerebrospinal fluid movement

doi:10.1186/2045-8118-11-16

. 2014 Jul 27;11:16.

doi: 10.1186/2045-8118-11-16. eCollection 2014.

A new look at cerebrospinal fluid movement

Darko Orešković¹, Marijan Klarica²

Affiliations

¹ Ruđer Bošković Institute, Department of Molecular Biology, Bijenička 54, 10 000 Zagreb, Croatia.
² Department of Pharmacology and Croatian Institute for Brain Research, School of Medicine University of Zagreb, Zagreb, Croatia ; Ruđer Bošković Institute, Department of Molecular Biology, Bijenička 54, 10 000 Zagreb, Croatia.

PMID: 25089184
PMCID: PMC4118619
DOI: 10.1186/2045-8118-11-16

Free PMC article

A new look at cerebrospinal fluid movement

Darko Orešković et al. Fluids Barriers CNS. 2014.

Free PMC article

. 2014 Jul 27;11:16.

doi: 10.1186/2045-8118-11-16. eCollection 2014.

Authors

Darko Orešković¹, Marijan Klarica²

Affiliations

¹ Ruđer Bošković Institute, Department of Molecular Biology, Bijenička 54, 10 000 Zagreb, Croatia.
² Department of Pharmacology and Croatian Institute for Brain Research, School of Medicine University of Zagreb, Zagreb, Croatia ; Ruđer Bošković Institute, Department of Molecular Biology, Bijenička 54, 10 000 Zagreb, Croatia.

PMID: 25089184
PMCID: PMC4118619
DOI: 10.1186/2045-8118-11-16

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Abstract

Brinker et al. extensively reviewed recent findings about CSF circulation in a recent article: "A new look at cerebrospinal circulation", but did not analyze some important available data in sufficient detail. For example, our findings as well as some clinical data and experimental results obtained from different animal species, do not support unidirectional CSF circulation but strongly suggest that there are cardiac cycle-dependent systolic-diastolic to-and-fro cranio-spinal CSF movements. These are based on: a) physiological oscillations of arterial and venous blood during cranio-spinal blood circulation; b) respiratory activity, and c) body activity and posture. That kind of complex CSF movement could explain the observed distribution of many different substances in all directions along the CSF system and within central nervous system tissue. It seems that efflux transport systems at capillary endothelium may be more important for brain homeostasis than the removal of metabolites by CSF flow. Thus, when discussing the CSF dynamics we suggest that a more appropriate term would be CSF movement rather than CSF circulation.

Keywords: Aquaporin; Cerebrospinal fluid circulation; Cerebrospinal fluid movement; Cerebrospinal fluid secretion; Classic hypothesis of cerebrospinal physiology; Orešković and Klarica hypothesis.

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References

1. Brinker T, Stopa E, Morrison J, Klinge P. A new look at cerebrospinal fluid circulation. Fluids Barriers CNS. 2014;11:10. doi: 10.1186/2045-8118-11-10. - DOI - PMC - PubMed
1. Dandy WE. Experimental hydrocephalus. Ann Surg. 1919;70:129–142. doi: 10.1097/00000658-191908000-00001. - DOI - PMC - PubMed
1. Orešković D, Klarica M, Vukić M. The formation and circulation of cerebrospinal fluid inside the cat brain ventricles: a fact or an illusion? Neurosci Lett. 2002;327:103–106. doi: 10.1016/S0304-3940(02)00395-6. - DOI - PubMed
1. Klarica M, Orešković D, Božić B, Vukić M, Butković V, Bulat M. New experimental model of acute aqueductal blockade in cats: Effects on cerebrospinal fluid pressure and the size of brain ventricles. Neurosci. 2009;158:1397–1405. doi: 10.1016/j.neuroscience.2008.11.041. - DOI - PubMed
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[1] Brinker T, Stopa E, Morrison J, Klinge P. A new look at cerebrospinal fluid circulation. Fluids Barriers CNS. 2014;11:10. doi: 10.1186/2045-8118-11-10. - DOI - PMC - PubMed

[2] Brinker T, Stopa E, Morrison J, Klinge P. A new look at cerebrospinal fluid circulation. Fluids Barriers CNS. 2014;11:10. doi: 10.1186/2045-8118-11-10. - DOI - PMC - PubMed

[3] Dandy WE. Experimental hydrocephalus. Ann Surg. 1919;70:129–142. doi: 10.1097/00000658-191908000-00001. - DOI - PMC - PubMed

[4] Dandy WE. Experimental hydrocephalus. Ann Surg. 1919;70:129–142. doi: 10.1097/00000658-191908000-00001. - DOI - PMC - PubMed

[5] Orešković D, Klarica M, Vukić M. The formation and circulation of cerebrospinal fluid inside the cat brain ventricles: a fact or an illusion? Neurosci Lett. 2002;327:103–106. doi: 10.1016/S0304-3940(02)00395-6. - DOI - PubMed

[6] Orešković D, Klarica M, Vukić M. The formation and circulation of cerebrospinal fluid inside the cat brain ventricles: a fact or an illusion? Neurosci Lett. 2002;327:103–106. doi: 10.1016/S0304-3940(02)00395-6. - DOI - PubMed

[7] Klarica M, Orešković D, Božić B, Vukić M, Butković V, Bulat M. New experimental model of acute aqueductal blockade in cats: Effects on cerebrospinal fluid pressure and the size of brain ventricles. Neurosci. 2009;158:1397–1405. doi: 10.1016/j.neuroscience.2008.11.041. - DOI - PubMed

[8] Klarica M, Orešković D, Božić B, Vukić M, Butković V, Bulat M. New experimental model of acute aqueductal blockade in cats: Effects on cerebrospinal fluid pressure and the size of brain ventricles. Neurosci. 2009;158:1397–1405. doi: 10.1016/j.neuroscience.2008.11.041. - DOI - PubMed

[9] Bulat M, Lupret V, Orešković D, Klarica M. Transventricular and transpial absorption of cerebrospinal fluid into cerebral microvessels. Coll Antropol. 2008;31(Suppl 3):43–50. - PubMed

[10] Bulat M, Lupret V, Orešković D, Klarica M. Transventricular and transpial absorption of cerebrospinal fluid into cerebral microvessels. Coll Antropol. 2008;31(Suppl 3):43–50. - PubMed

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A new look at cerebrospinal fluid movement

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A new look at cerebrospinal fluid movement

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Cited by 17 articles

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