Red cabbage (Brassica oleracea L.) mediates redox-sensitive amelioration of dyslipidemia and hepatic injury induced by exogenous cholesterol administration
- PMID: 24467544
- DOI: 10.1142/S0192415X1450013X
Red cabbage (Brassica oleracea L.) mediates redox-sensitive amelioration of dyslipidemia and hepatic injury induced by exogenous cholesterol administration
Abstract
The widely used culinary vegetable, red cabbage (Brassica oleracea L. Var. capitata f. rubra), of the Brassicaceae family contains biologically potent anthocyanins and a myriad of antioxidants. Previous studies have shown that the pharmacological effects of red cabbage in vivo are redox-sensitive. The present study explored whether red cabbage modulates various histopathological and biochemical parameters in rats administered with a cholesterol-rich diet (CRD). To this end, prolonged administration of a lyophilized-aqueous extract of red cabbage (250 and 500 mg/kg body weight) significantly blunted the imbalances in lipids, liver enzymes and renal osmolytes induced by the CRD. The effects of red cabbage were compared to simvastatin (30 mg/kg body weight) treated rats. Estimation of malondialdehyde and non-protein sulfhydryls revealed robust antioxidant properties of red cabbage. Histopathological analysis of livers from rats administered with red cabbage showed marked inhibition in inflammatory and necrotic changes triggered by CRD. Similarly, in vitro studies using a 2',7'-Dichlorofluorescein-based assay showed that red cabbage conferred cytoprotective effects in cultured HepG2 cells. In conclusion, the present study discloses the potential therapeutic effects of red cabbage in dyslipidemia as well as hepatic injury, that is at least, partly mediated by its antioxidant properties.
Similar articles
-
Anthocyanin-rich red cabbage (Brassica oleracea L.) extract attenuates cardiac and hepatic oxidative stress in rats fed an atherogenic diet.J Sci Food Agric. 2012 Jun;92(8):1688-93. doi: 10.1002/jsfa.5532. Epub 2012 Jan 6. J Sci Food Agric. 2012. PMID: 22228433
-
Assessment of bioactive metabolites and hypolipidemic effect of polyphenolic-rich red cabbage extract.Pharm Biol. 2016 Dec;54(12):3033-3039. doi: 10.1080/13880209.2016.1200633. Epub 2016 Jul 19. Pharm Biol. 2016. PMID: 27436527
-
effect of dose size on bioavailability of acylated and nonacylated anthocyanins from red cabbage (Brassica oleracea L. Var. capitata).J Agric Food Chem. 2007 Jun 27;55(13):5354-62. doi: 10.1021/jf0710736. Epub 2007 Jun 2. J Agric Food Chem. 2007. PMID: 17542615 Clinical Trial.
-
Tissue culture and genetic transformation of cabbage (Brassica oleracea var. capitata): an overview.Planta. 2018 Nov;248(5):1037-1048. doi: 10.1007/s00425-018-2961-3. Epub 2018 Jul 31. Planta. 2018. PMID: 30066219 Free PMC article. Review.
-
Cancer preventive properties of varieties of Brassica oleracea: a review.Am J Clin Nutr. 1994 May;59(5 Suppl):1166S-1170S. doi: 10.1093/ajcn/59.5.1166S. Am J Clin Nutr. 1994. PMID: 8172118 Review.
Cited by 2 articles
-
Effects of High Consumption of Vegetables on Clinical, Immunological, and Antioxidant Markers in Subjects at Risk of Cardiovascular Diseases.Oxid Med Cell Longev. 2018 Oct 8;2018:5417165. doi: 10.1155/2018/5417165. eCollection 2018. Oxid Med Cell Longev. 2018. PMID: 30402206 Free PMC article.
-
Cabbage (Brassica oleracea var. capitata) Protects against H2O2-Induced Oxidative Stress by Preventing Mitochondrial Dysfunction in H9c2 Cardiomyoblasts.Evid Based Complement Alternat Med. 2018 Aug 12;2018:2179021. doi: 10.1155/2018/2179021. eCollection 2018. Evid Based Complement Alternat Med. 2018. PMID: 30158990 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
-
Full Text Sources
-
Other Literature Sources
-
Medical