Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Aug 10;11:95.
doi: 10.1186/1475-2840-11-95.

GC-MS analysis and screening of antidiabetic, antioxidant and hypolipidemic potential of Cinnamomum tamala oil in streptozotocin induced diabetes mellitus in rats

Suresh Kumar  1 , Neeru Vasudeva, Sunil Sharma
Affiliations
Free PMC article

GC-MS analysis and screening of antidiabetic, antioxidant and hypolipidemic potential of Cinnamomum tamala oil in streptozotocin induced diabetes mellitus in rats

Suresh Kumar et al. Cardiovasc Diabetol. .
Free PMC article
Favorites

Abstract

Aim of the study: This study was made to investigate the antidiabetic, antioxidant and hypolipidemic potential of Cinnamomum tamala, (Buch.-Ham.) Nees & Eberm (Tejpat) oil (CTO) in streptozotocin (STZ) induced diabetes in rats along with evaluation of chemical constituents.

Materials and methods: The GC-MS (Gas chromatography-mass spectrometry) analysis of the oil showed 31 constituents of which cinnamaldehyde was found the major component (44.898%). CTO and cinnamaldehyde was orally administered to diabetic rats to study its effect in both acute and chronic antihyperglycemic models. The body weight, oral glucose tolerance test and biochemical parameters viz. glucose level, insulin level, liver glycogen content, glycosylated hemoglobin, total plasma cholesterol, triglyceride and antioxidant parameters were estimated for all treated groups and compared against diabetic control group.

Results: CTO (100 mg/kg and 200 mg/kg), cinnamaldehyde (20 mg/kg) and glibenclamide (0.6 mg/kg) in respective groups of diabetic animals administered for 28 days reduced the blood glucose level in streptozotocin induced diabetic rats. There was significant increase in body weight, liver glycogen content, plasma insulin level and decrease in the blood glucose, glycosylated hemoglobin and total plasma cholesterol in test groups as compared to control group. The results of CTO and cinnamaldehyde were found comparable with standard drug glibenclamide. In vitro antioxidant studies on CTO using various models showed significant antioxidant activity. In vivo antioxidant studies on STZ induced diabetic rats revealed decreased malondialdehyde (MDA) and increased reduced glutathione (GSH).

Conclusion: Thus the investigation results that CTO has significant antidiabetic, antioxidant and hypolipidemic activity.

Figures

Figure 1
GC-MS chromatogram of Cinnamomum tamala oil shows 31 peaks which indicates that 31 compounds are present in the plant oil.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by 12 articles

See all "Cited by" articles

References

    1. Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature. 2001;414:782–787. - PubMed
    1. Harris MI, Hadden WC, Knowler WC, Bennett PH. Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in U.S. population aged 20–74. Diabetes. 1987;36:523–534. - PubMed
    1. Dennery PA. Introduction to serial review on the role of oxidative stress in diabetes mellitus. Free Radic Biol Med. 2006;40(1):1–2. - PubMed
    1. Baynes JW. Role of oxidative stress in development of complications in diabetes. Diabetes. 1991;40:9–21. - PubMed
    1. Kar A, Choudhary BK, Bandyopadhyay NG. Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats. J Ethnopharmacol. 2003;84:105–108. - PubMed

MeSH terms

Feedback