A morphometric study on the development of the lateral ventricle choroid plexus, choroid plexus capillaries and ventricular ependyma in the rat
- PMID: 2279331
- DOI: 10.1016/0165-3806(90)90163-s
A morphometric study on the development of the lateral ventricle choroid plexus, choroid plexus capillaries and ventricular ependyma in the rat
Abstract
Morphometric changes in the rat lateral ventricle choroid plexus epithelium and endothelium and in the ventricular ependyma were studied between 16 days gestation and 30 days after birth, using stereological techniques. The epithelial apical surface density increased from 0.6 to 3.3 microns 2/microns 3 and the mitochondrial volume fraction from 3.2 to 7.6% during this period. The endothelial fenestrations increased from 0.05 to 0.39 micron-1. These changes may be related to postnatal increases in choroid plexus function. Morphological changes in basolateral surface density, cell height and nucleus and glycogen volume fraction have also been measured. The development of the lateral ventricle choroid plexus was qualitatively similar to the fourth ventricle plexus reported previously, but small quantitative differences occurred. The ventricular ependyma also showed a significant increase in mitochondrial volume fraction after birth, though to a lesser extent than the plexus epithelium. The total apical surface area of the choroid plexuses was estimated at 75 cm2 for 30-day-old rats. This figure, which takes into account the apical microvilli, is much greater than previous estimates and is similar to the surface area of the cerebral capillaries (155 cm2), and suggests that the choroid plexuses may play a more important role in the regulation of the brain microenvironment than previously thought.
Similar articles
-
A morphometric analysis of the development of the fourth ventricle choroid plexus in the rat.Brain Res. 1986 Jun;392(1-2):77-85. doi: 10.1016/0165-3806(86)90234-8. Brain Res. 1986. PMID: 3708386
-
A quantitative study of cell proliferation in ependyma and choroid plexus in the postnatal rat brain.Neuropathol Appl Neurobiol. 1979 Aug;5(4):303-9. doi: 10.1111/j.1365-2990.1979.tb00629.x. Neuropathol Appl Neurobiol. 1979. PMID: 481702
-
The lateral, third, and fourth ventricle choroid plexus of the dog: a structural and ultrastructural study.Ann Neurol. 1981 Oct;10(4):333-40. doi: 10.1002/ana.410100404. Ann Neurol. 1981. PMID: 7316486
-
Histochemistry and immunocytochemistry of the developing ependyma and choroid plexus.Microsc Res Tech. 1998 Apr 1;41(1):14-28. doi: 10.1002/(SICI)1097-0029(19980401)41:1<14::AID-JEMT3>3.0.CO;2-U. Microsc Res Tech. 1998. PMID: 9550134 Review.
-
Studies on the choroid plexus.Neurosci Res (N Y). 1970;3:131-73. doi: 10.1016/b978-0-12-512503-1.50009-8. Neurosci Res (N Y). 1970. PMID: 4263247 Review. No abstract available.
Cited by 56 articles
-
Choroid Plexus: The Orchestrator of Long-Range Signalling Within the CNS.Int J Mol Sci. 2020 Jul 4;21(13):4760. doi: 10.3390/ijms21134760. Int J Mol Sci. 2020. PMID: 32635478 Free PMC article. Review.
-
Perivascular Unit: This Must Be the Place. The Anatomical Crossroad Between the Immune, Vascular and Nervous System.Front Neuroanat. 2020 Apr 16;14:17. doi: 10.3389/fnana.2020.00017. eCollection 2020. Front Neuroanat. 2020. PMID: 32372921 Free PMC article. Review.
-
Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets.Nat Rev Neurol. 2020 May;16(5):285-296. doi: 10.1038/s41582-020-0321-y. Epub 2020 Mar 9. Nat Rev Neurol. 2020. PMID: 32152460 Review.
-
Blood-Brain Barrier and Delivery of Protein and Gene Therapeutics to Brain.Front Aging Neurosci. 2020 Jan 10;11:373. doi: 10.3389/fnagi.2019.00373. eCollection 2019. Front Aging Neurosci. 2020. PMID: 31998120 Free PMC article.
-
How does the brain remove its waste metabolites from within?Int J Physiol Pathophysiol Pharmacol. 2019 Dec 15;11(6):238-249. eCollection 2019. Int J Physiol Pathophysiol Pharmacol. 2019. PMID: 31993098 Free PMC article. Review.
Publication types
MeSH terms
Grant support
LinkOut - more resources
-
Full Text Sources
-
Other Literature Sources
-
Medical