Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes
- PMID: 22749176
- DOI: 10.1016/j.nutres.2012.05.003
Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes
Abstract
For thousands of years, cinnamon has been used as a traditional treatment in China. However, there are no studies to date that investigate whether cinnamon supplements are able to aid in the treatment of type 2 diabetes in Chinese subjects. We hypothesized cinnamon should be effective in improving blood glucose control in Chinese patients with type 2 diabetes. To address this hypothesis, we performed a randomized, double-blinded clinical study to analyze the effect of cinnamon extract on glycosylated hemoglobin A(1c) and fasting blood glucose levels in Chinese patients with type 2 diabetes. A total of 66 patients with type 2 diabetes were recruited and randomly divided into 3 groups: placebo and low-dose and high-dose supplementation with cinnamon extract at 120 and 360 mg/d, respectively. Patients in all 3 groups took gliclazide during the entire 3 months of the study. Both hemoglobin A(1c) and fasting blood glucose levels were significantly reduced in patients in the low- and high-dose groups, whereas they were not changed in the placebo group. The blood triglyceride levels were also significantly reduced in the low-dose group. The blood levels of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and liver transaminase remained unchanged in the 3 groups. In conclusion, our study indicates that cinnamon supplementation is able to significantly improve blood glucose control in Chinese patients with type 2 diabetes.
Copyright © 2012 Elsevier Inc. All rights reserved.
Similar articles
-
Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2.Eur J Clin Invest. 2006 May;36(5):340-4. doi: 10.1111/j.1365-2362.2006.01629.x. Eur J Clin Invest. 2006. PMID: 16634838 Clinical Trial.
-
Cinnamomum zeylanicum (Ceylon cinnamon) as a potential pharmaceutical agent for type-2 diabetes mellitus: study protocol for a randomized controlled trial.Trials. 2017 Sep 29;18(1):446. doi: 10.1186/s13063-017-2192-0. Trials. 2017. PMID: 28962661 Free PMC article. Clinical Trial.
-
The potential of cinnamon to reduce blood glucose levels in patients with type 2 diabetes and insulin resistance.Diabetes Obes Metab. 2009 Dec;11(12):1100-13. doi: 10.1111/j.1463-1326.2009.01094.x. Diabetes Obes Metab. 2009. PMID: 19930003 Review.
-
Results of the glucose-lowering effect of WelChol study (GLOWS): a randomized, double-blind, placebo-controlled pilot study evaluating the effect of colesevelam hydrochloride on glycemic control in subjects with type 2 diabetes.Clin Ther. 2007 Jan;29(1):74-83. doi: 10.1016/j.clinthera.2007.01.003. Clin Ther. 2007. PMID: 17379048 Clinical Trial.
-
Cinnamon supplementation in patients with type 2 diabetes mellitus.Pharmacotherapy. 2007 Apr;27(4):595-9. doi: 10.1592/phco.27.4.595. Pharmacotherapy. 2007. PMID: 17381386 Review.
Cited by 28 articles
-
Cinnamon extract supplementation improves inflammation and oxidative stress induced by acrylamide: An experimental animal study.Avicenna J Phytomed. 2020 May-Jun;10(3):243-252. Avicenna J Phytomed. 2020. PMID: 32523879 Free PMC article.
-
The Effect of Diacerein on Type 2 Diabetic Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis.J Diabetes Res. 2020 Feb 10;2020:2593792. doi: 10.1155/2020/2593792. eCollection 2020. J Diabetes Res. 2020. PMID: 32104712 Free PMC article. Review.
-
The Effect of Different Amounts of Cinnamon Consumption on Blood Glucose in Healthy Adult Individuals.Int J Food Sci. 2019 Mar 4;2019:4138534. doi: 10.1155/2019/4138534. eCollection 2019. Int J Food Sci. 2019. PMID: 30949494 Free PMC article.
-
Polyherbal dietary supplementation for prediabetic adults: study protocol for a randomized controlled trial.Trials. 2019 Jan 7;20(1):24. doi: 10.1186/s13063-018-3032-6. Trials. 2019. PMID: 30616613 Free PMC article. Clinical Trial.
-
Study of the effect of the herbal composition SR2004 on hemoglobin A1c, fasting blood glucose, and lipids in patients with type 2 diabetes mellitus.Integr Med Res. 2018 Sep;7(3):248-256. doi: 10.1016/j.imr.2018.04.002. Epub 2018 Apr 30. Integr Med Res. 2018. PMID: 30271713 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
-
Full Text Sources
-
Other Literature Sources
-
Medical