Probiotic yogurt improves antioxidant status in type 2 diabetic patients
- PMID: 22129852
- DOI: 10.1016/j.nut.2011.08.013
Probiotic yogurt improves antioxidant status in type 2 diabetic patients
Abstract
Objective: Oxidative stress plays a major role in the pathogenesis and progression of diabetes. Among various functional foods with an antioxidant effect, probiotic foods have been reported to repress oxidative stress. The objective of this clinical trial was to assess the effects of probiotic and conventional yogurt on blood glucose and antioxidant status in type 2 diabetic patients.
Methods: Sixty-four patients with type 2 diabetes mellitus, 30 to 60 y old, were assigned to two groups in this randomized, double-blind, controlled clinical trial. The patients in the intervention group consumed 300 g/d of probiotic yogurt containing Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 and those in the control group consumed 300 g/d of conventional yogurt for 6 wk. Fasting blood samples, 24-h dietary recalls, and anthropometric measurements were collected at the baseline and at the end of the trial.
Results: Probiotic yogurt significantly decreased fasting blood glucose (P < 0.01) and hemoglobin A1c (P < 0.05) and increased erythrocyte superoxide dismutase and glutathione peroxidase activities and total antioxidant status (P < 0.05) compared with the control group. In addition, the serum malondialdehyde concentration significantly decreased compared with the baseline value in both groups (P < 0.05). No significant changes from baseline were shown in insulin concentration and erythrocyte catalase activity within either group (P > 0.05).
Conclusion: The consumption of probiotic yogurt improved fasting blood glucose and antioxidant status in type 2 diabetic patients. These results suggest that probiotic yogurt is a promising agent for diabetes management.
Copyright © 2012 Elsevier Inc. All rights reserved.
Similar articles
-
Effect of probiotic yogurt containing Lactobacillus acidophilus and Bifidobacterium lactis on lipid profile in individuals with type 2 diabetes mellitus.J Dairy Sci. 2011 Jul;94(7):3288-94. doi: 10.3168/jds.2010-4128. J Dairy Sci. 2011. PMID: 21700013 Clinical Trial.
-
Effect of daily consumption of probiotic yogurt on oxidative stress in pregnant women: a randomized controlled clinical trial.Ann Nutr Metab. 2012;60(1):62-8. doi: 10.1159/000335468. Epub 2012 Feb 10. Ann Nutr Metab. 2012. PMID: 22338626 Clinical Trial.
-
Effect of multispecies probiotic supplements on metabolic profiles, hs-CRP, and oxidative stress in patients with type 2 diabetes.Ann Nutr Metab. 2013;63(1-2):1-9. doi: 10.1159/000349922. Epub 2013 Jul 5. Ann Nutr Metab. 2013. PMID: 23899653 Clinical Trial.
-
The Effect of Probiotic Yogurt on Glycemic Control in Type 2 Diabetes or Obesity: A Meta-Analysis of Nine Randomized Controlled Trials.Nutrients. 2019 Mar 20;11(3):671. doi: 10.3390/nu11030671. Nutrients. 2019. PMID: 30897796 Free PMC article. Review.
-
Effects of probiotic supplementation in patients with type 2 diabetes: systematic review and meta-analysis.Nutr Rev. 2016 Dec;74(12):774-784. doi: 10.1093/nutrit/nuw039. Nutr Rev. 2016. PMID: 27864537 Review.
Cited by 113 articles
-
An Overview on Probiotics as an Alternative Strategy for Prevention and Treatment of Human Diseases.Iran J Pharm Res. 2019 Fall;18(Suppl1):31-50. doi: 10.22037/ijpr.2020.112232.13620. Iran J Pharm Res. 2019. PMID: 32802088 Free PMC article. Review.
-
Probiotic treatment for women with gestational diabetes to improve maternal and infant health and well-being.Cochrane Database Syst Rev. 2020 Jun 24;6(6):CD012970. doi: 10.1002/14651858.CD012970.pub2. Cochrane Database Syst Rev. 2020. PMID: 32575163
-
The food-gut axis: lactic acid bacteria and their link to food, the gut microbiome and human health.FEMS Microbiol Rev. 2020 Jul 1;44(4):454-489. doi: 10.1093/femsre/fuaa015. FEMS Microbiol Rev. 2020. PMID: 32556166 Free PMC article.
-
Fermented Dairy Products, Probiotic Supplementation, and Cardiometabolic Diseases: A Systematic Review and Meta-analysis.Adv Nutr. 2020 Jul 1;11(4):834-863. doi: 10.1093/advances/nmaa030. Adv Nutr. 2020. PMID: 32277831
-
Probiotics against alleviation of lead toxicity: recent advances.Interdiscip Toxicol. 2019 Oct;12(2):89-92. doi: 10.2478/intox-2019-0010. Epub 2020 Feb 20. Interdiscip Toxicol. 2019. PMID: 32206029 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
-
Full Text Sources
-
Other Literature Sources
-
Medical