Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis
- PMID: 21899805
- DOI: 10.1017/S0007114511004260
Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis
Abstract
Lutein and zeaxanthin are thought to decrease the incidence of age-related macular degeneration (AMD); however, findings have been inconsistent. We conducted a systematic literature review and meta-analysis to evaluate the relationship between dietary intake of lutein and zeaxanthin and AMD risk. Relevant studies were identified by searching five databases up to April 2010. Reference lists of articles were retrieved, and experts were contacted. Literature search, data extraction and study quality assessment were performed independently by two reviewers and results were pooled quantitatively using meta-analysis methods. The potential sources of heterogeneity and publication bias were also estimated. The search yielded six longitudinal cohort studies. The pooled relative risk (RR) for early AMD, comparing the highest with the lowest category of lutein and zeaxanthin intake, was 0·96 (95 % CI 0·78, 1·17). Dietary intake of these carotenoids was significantly related with a reduction in risk of late AMD (RR 0·74; 95 % CI 0·57, 0·97); and a statistically significant inverse association was observed between lutein and zeaxanthin intake and neovascular AMD risk (RR 0·68; 95 % CI 0·51, 0·92). The results were essentially consistent among subgroups stratified by participant characteristics. The findings of the present meta-analysis indicate that dietary lutein and zeaxanthin is not significantly associated with a reduced risk of early AMD, whereas an increase in the intake of these carotenoids may be protective against late AMD. However, additional studies are needed to confirm these relationships.
Similar articles
-
Prospective study of lutein/zeaxanthin intake and risk of age-related macular degeneration.Am J Clin Nutr. 2008 Jun;87(6):1837-43. doi: 10.1093/ajcn/87.6.1837. Am J Clin Nutr. 2008. PMID: 18541575 Free PMC article. Clinical Trial.
-
Associations between intermediate age-related macular degeneration and lutein and zeaxanthin in the Carotenoids in Age-related Eye Disease Study (CAREDS): ancillary study of the Women's Health Initiative.Arch Ophthalmol. 2006 Aug;124(8):1151-62. doi: 10.1001/archopht.124.8.1151. Arch Ophthalmol. 2006. PMID: 16908818
-
Lutein and zeaxanthin for macular degeneration.Am J Health Syst Pharm. 2008 Jul 1;65(13):1232-8. doi: 10.2146/ahjp080052. Am J Health Syst Pharm. 2008. PMID: 18574012
-
Associations between lutein, zeaxanthin, and age-related macular degeneration: an overview.Crit Rev Food Sci Nutr. 2009 Apr;49(4):313-26. doi: 10.1080/10408390802066979. Crit Rev Food Sci Nutr. 2009. PMID: 19234943 Review.
-
Dietary sources of lutein and zeaxanthin carotenoids and their role in eye health.Nutrients. 2013 Apr 9;5(4):1169-85. doi: 10.3390/nu5041169. Nutrients. 2013. PMID: 23571649 Free PMC article. Review.
Cited by 39 articles
-
The potential health benefits of dietary natural plant products in age related eye diseases.Heliyon. 2020 Jul 10;6(7):e04408. doi: 10.1016/j.heliyon.2020.e04408. eCollection 2020 Jul. Heliyon. 2020. PMID: 32685729 Free PMC article. Review.
-
Mitochondrial Dysfunction as a Novel Target for Neuroprotective Nutraceuticals in Ocular Diseases.Nutrients. 2020 Jun 30;12(7):1950. doi: 10.3390/nu12071950. Nutrients. 2020. PMID: 32629966 Free PMC article. Review.
-
Isolation and Characterization of Novel Chlorella Vulgaris Mutants With Low Chlorophyll and Improved Protein Contents for Food Applications.Front Bioeng Biotechnol. 2020 May 19;8:469. doi: 10.3389/fbioe.2020.00469. eCollection 2020. Front Bioeng Biotechnol. 2020. PMID: 32509750 Free PMC article.
-
Sea Buckthorn Oil as a Valuable Source of Bioaccessible Xanthophylls.Nutrients. 2019 Dec 27;12(1):76. doi: 10.3390/nu12010076. Nutrients. 2019. PMID: 31892138 Free PMC article.
-
Association of Dietary and Supplementary Calcium Intake With Age-Related Macular Degeneration: Age-Related Eye Disease Study Report 39.JAMA Ophthalmol. 2019 May 1;137(5):543-550. doi: 10.1001/jamaophthalmol.2019.0292. JAMA Ophthalmol. 2019. PMID: 30896764 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
-
Full Text Sources
-
Other Literature Sources
-
Medical
-
Miscellaneous