Broccoli sprouts reduce oxidative stress in type 2 diabetes: a randomized double-blind clinical trial
- PMID: 21559038
- DOI: 10.1038/ejcn.2011.59
Broccoli sprouts reduce oxidative stress in type 2 diabetes: a randomized double-blind clinical trial
Abstract
Background/objectives: In vitro and animal studies have reported that young broccoli sprouts improve oxidative stress status in diabetic condition. The objective of this double-blind, placebo-controlled, randomized clinical trial was to investigate the effects of broccoli sprouts powder (BSP) on some oxidative stress parameters in type 2 diabetes patients.
Subjects/methods: A total of 81 patients with type 2 diabetes were randomly assigned to one of three treatment groups for 4 weeks. The groups received either 10 g/d BSP (n=27), 5 g/d BSP (n=29) or placebo (n=25). Serum total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), malondialdehyde (MDA) and oxidized low density lipoprotein (LDL) cholesterol were measured at baseline and at 4 weeks after treatment.
Results: In all, 63 patients in three groups were included in the analysis: 10 g/d BSP (n=21), 5 g/d (n=22) and placebo (n=20). After 4 weeks, consumption of BSP resulted in significant decrease in MDA (P=0.001 for treatment effect), oxidized low density lipoprotein cholesterol (P=0.03 for treatment effect), OSI (P=0.001 for treatment effect) and significant increase in TAC (P=0.001 for treatment effect). No effects were found on TOS.
Conclusion: BSP had favorable effects on oxidative stress status in type 2 diabetes patients.
Similar articles
-
Broccoli sprouts powder could improve serum triglyceride and oxidized LDL/LDL-cholesterol ratio in type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial.Diabetes Res Clin Pract. 2012 Jun;96(3):348-54. doi: 10.1016/j.diabres.2012.01.009. Epub 2012 Feb 9. Diabetes Res Clin Pract. 2012. PMID: 22325157 Clinical Trial.
-
Effects of antioxidant supplementation on postprandial oxidative stress and endothelial dysfunction: a single-blind, 15-day clinical trial in patients with untreated type 2 diabetes, subjects with impaired glucose tolerance, and healthy controls.Clin Ther. 2005 Nov;27(11):1764-73. doi: 10.1016/j.clinthera.2005.11.006. Clin Ther. 2005. PMID: 16368447 Clinical Trial.
-
Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity.Diabet Med. 2009 May;26(5):526-31. doi: 10.1111/j.1464-5491.2009.02727.x. Diabet Med. 2009. PMID: 19646193 Clinical Trial.
-
Oxidative stress in hemodialysis patients receiving intravenous iron therapy and the role of N-acetylcysteine in preventing oxidative stress.Saudi J Kidney Dis Transpl. 2010 Sep;21(5):852-8. Saudi J Kidney Dis Transpl. 2010. PMID: 20814119 Clinical Trial.
-
Potential efficacy of broccoli sprouts as a unique supplement for management of type 2 diabetes and its complications.J Med Food. 2013 May;16(5):375-82. doi: 10.1089/jmf.2012.2559. Epub 2013 Apr 30. J Med Food. 2013. PMID: 23631497 Review.
Cited by 20 articles
-
Sulforaphane: Its "Coming of Age" as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease.Oxid Med Cell Longev. 2019 Oct 14;2019:2716870. doi: 10.1155/2019/2716870. eCollection 2019. Oxid Med Cell Longev. 2019. PMID: 31737167 Free PMC article. Review.
-
Broccoli or Sulforaphane: Is It the Source or Dose That Matters?Molecules. 2019 Oct 6;24(19):3593. doi: 10.3390/molecules24193593. Molecules. 2019. PMID: 31590459 Free PMC article. Review.
-
Relation of Fruits and Vegetables with Major Cardiometabolic Risk Factors, Markers of Oxidation, and Inflammation.Nutrients. 2019 Oct 6;11(10):2381. doi: 10.3390/nu11102381. Nutrients. 2019. PMID: 31590420 Free PMC article. Review.
-
Short-Term Dietary Intervention with Cooked but Not Raw Brassica Leafy Vegetables Increases Telomerase Activity in CD8+ Lymphocytes in a Randomized Human Trial.Nutrients. 2019 Apr 5;11(4):786. doi: 10.3390/nu11040786. Nutrients. 2019. PMID: 30959753 Free PMC article. Clinical Trial.
-
Sorting out the Value of Cruciferous Sprouts as Sources of Bioactive Compounds for Nutrition and Health.Nutrients. 2019 Feb 19;11(2):429. doi: 10.3390/nu11020429. Nutrients. 2019. PMID: 30791362 Free PMC article. Review.