Neuronal activity regulates the regional vulnerability to amyloid-β deposition
- PMID: 21532579
- PMCID: PMC3102784
- DOI: 10.1038/nn.2801
Neuronal activity regulates the regional vulnerability to amyloid-β deposition
Abstract
Amyloid-β (Aβ) plaque deposition in specific brain regions is a pathological hallmark of Alzheimer's disease. However, the mechanism underlying the regional vulnerability to Aβ deposition in Alzheimer's disease is unknown. Herein, we provide evidence that endogenous neuronal activity regulates the regional concentration of interstitial fluid (ISF) Aβ, which drives local Aβ aggregation. Using in vivo microdialysis, we show that ISF Aβ concentrations in several brain regions of APP transgenic mice before plaque deposition were commensurate with the degree of subsequent plaque deposition and with the concentration of lactate, a marker of neuronal activity. Furthermore, unilateral vibrissal stimulation increased ISF Aβ, and unilateral vibrissal deprivation decreased ISF Aβ and lactate, in contralateral barrel cortex. Long-term unilateral vibrissal deprivation decreased amyloid plaque formation and growth. Our results suggest a mechanism to account for the vulnerability of specific brain regions to Aβ deposition in Alzheimer's disease.
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Comment in
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Amyloid by default.Nat Neurosci. 2011 Jun;14(6):669-70. doi: 10.1038/nn.2853. Nat Neurosci. 2011. PMID: 21613991 No abstract available.
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Neurodegenerative disease: directing amyloid-β deposition.Nat Rev Neurosci. 2011 Jun 2;12(7):372-3. doi: 10.1038/nrn3059. Nat Rev Neurosci. 2011. PMID: 21633382 No abstract available.
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