Cinnamon intake lowers fasting blood glucose: meta-analysis
- PMID: 21480806
- DOI: 10.1089/jmf.2010.0180
Cinnamon intake lowers fasting blood glucose: meta-analysis
Abstract
Cinnamon, the dry bark and twig of Cinnamomum spp., is a rich botanical source of polyphenolics that has been used for centuries in Chinese medicine and has been shown to affect blood glucose and insulin signaling. Cinnamon's effects on blood glucose have been the subject of many clinical and animal studies; however, the issue of cinnamon intake's effect on fasting blood glucose (FBG) in people with type 2 diabetes and/or prediabetes still remains unclear. A meta-analysis of clinical studies of the effect of cinnamon intake on people with type 2 diabetes and/or prediabetes that included three new clinical trials along with five trials used in previous meta-analyses was done to assess cinnamon's effectiveness in lowering FBG. The eight clinical studies were identified using a literature search (Pub Med and Biosis through May 2010) of randomized, placebo-controlled trials reporting data on cinnamon and/or cinnamon extract and FBG. Comprehensive Meta-Analysis (Biostat Inc., Englewood, NJ, USA) was performed on the identified data for both cinnamon and cinnamon extract intake using a random-effects model that determined the standardized mean difference ([i.e., Change 1(control) - Change 2(cinnamon)] divided by the pooled SD of the post scores). Cinnamon intake, either as whole cinnamon or as cinnamon extract, results in a statistically significant lowering in FBG (-0.49±0.2 mmol/L; n=8, P=.025) and intake of cinnamon extract only also lowered FBG (-0.48 mmol/L±0.17; n=5, P=.008). Thus cinnamon extract and/or cinnamon improves FBG in people with type 2 diabetes or prediabetes.
Similar articles
-
Effect of cinnamon on glucose control and lipid parameters.Diabetes Care. 2008 Jan;31(1):41-3. doi: 10.2337/dc07-1711. Epub 2007 Oct 1. Diabetes Care. 2008. PMID: 17909085
-
Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes.Nutr Res. 2012 Jun;32(6):408-12. doi: 10.1016/j.nutres.2012.05.003. Epub 2012 Jun 14. Nutr Res. 2012. PMID: 22749176 Clinical Trial.
-
Effect of short-term administration of cinnamon on blood pressure in patients with prediabetes and type 2 diabetes.Nutrition. 2013 Oct;29(10):1192-6. doi: 10.1016/j.nut.2013.03.007. Epub 2013 Jul 16. Nutrition. 2013. PMID: 23867208 Review.
-
The potential of cinnamon to reduce blood glucose levels in patients with type 2 diabetes and insulin resistance.Diabetes Obes Metab. 2009 Dec;11(12):1100-13. doi: 10.1111/j.1463-1326.2009.01094.x. Diabetes Obes Metab. 2009. PMID: 19930003 Review.
-
Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae (Cinnamon bark) extract in C57BL/Ks db/db mice.Arch Pharm Res. 2010 Feb;33(2):325-33. doi: 10.1007/s12272-010-0219-0. Epub 2010 Feb 24. Arch Pharm Res. 2010. PMID: 20195835
Cited by 22 articles
-
Dietary Polyphenols and Gene Expression in Molecular Pathways Associated with Type 2 Diabetes Mellitus: A Review.Int J Mol Sci. 2019 Dec 24;21(1):140. doi: 10.3390/ijms21010140. Int J Mol Sci. 2019. PMID: 31878222 Free PMC article. Review.
-
Hesperidin supplementation has no effect on blood glucose control: A systematic review and meta-analysis of randomized controlled clinical trials.Br J Clin Pharmacol. 2020 Jan;86(1):13-22. doi: 10.1111/bcp.14120. Epub 2019 Dec 12. Br J Clin Pharmacol. 2020. PMID: 31489695 Review.
-
Evaluation of relaxant responses properties of cinnamon essential oil and its major component, cinnamaldehyde on human and rat corpus cavernosum.Int Braz J Urol. 2019 Sep-Oct;45(5):1033-1042. doi: 10.1590/S1677-5538.IBJU.2019.0016. Int Braz J Urol. 2019. PMID: 31408283 Free PMC article.
-
Polyphenols for diabetes associated neuropathy: Pharmacological targets and clinical perspective.Daru. 2019 Dec;27(2):781-798. doi: 10.1007/s40199-019-00289-w. Epub 2019 Jul 27. Daru. 2019. PMID: 31352568 Free PMC article. Review.
-
The Effect of Different Amounts of Cinnamon Consumption on Blood Glucose in Healthy Adult Individuals.Int J Food Sci. 2019 Mar 4;2019:4138534. doi: 10.1155/2019/4138534. eCollection 2019. Int J Food Sci. 2019. PMID: 30949494 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
-
Full Text Sources
-
Medical
-
Miscellaneous