Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomised controlled trial
- PMID: 20594781
- DOI: 10.1016/j.maturitas.2010.06.001
Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomised controlled trial
Abstract
Objective: To assess the effect, tolerability and acceptability of aged garlic extract as an adjunct treatment to existing antihypertensive medication in patients with treated, but uncontrolled, hypertension.
Design: A double-blind parallel randomised placebo-controlled trial involving 50 patients whose routine clinical records in general practice documented treated but uncontrolled hypertension. The active treatment group received four capsules of aged garlic extract (960 mg containing 2.4 mg S-allylcysteine) daily for 12 weeks, and the control group received matching placebos. The primary outcome measures were systolic and diastolic blood pressure at baseline, 4, 8 and 12 weeks, and change over time. We also assessed tolerability during the trial and acceptability at 12 weeks.
Results: In patients with uncontrolled hypertension (SBP ≥ 140 mmHg at baseline), systolic blood pressure was on average 10.2 ± 4.3 mmHg (p=0.03) lower in the garlic group compared with controls over the 12-week treatment period. Changes in blood pressure between the groups were not significant in patients with SBP<140 mmHg at baseline. Aged garlic extract was generally well tolerated and acceptability of trial treatment was high (92%).
Conclusion: Our trial suggests that aged garlic extract is superior to placebo in lowering systolic blood pressure similarly to current first line medications in patients with treated but uncontrolled hypertension.
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Similar articles
-
Aged garlic extract reduces blood pressure in hypertensives: a dose-response trial.Eur J Clin Nutr. 2013 Jan;67(1):64-70. doi: 10.1038/ejcn.2012.178. Epub 2012 Nov 21. Eur J Clin Nutr. 2013. PMID: 23169470 Free PMC article. Clinical Trial.
-
Clinical effects produced by a standardized herbal medicinal product of Hibiscus sabdariffa on patients with hypertension. A randomized, double-blind, lisinopril-controlled clinical trial.Planta Med. 2007 Jan;73(1):6-12. doi: 10.1055/s-2006-957065. Planta Med. 2007. PMID: 17315307 Clinical Trial.
-
Aged garlic extract supplemented with B vitamins, folic acid and L-arginine retards the progression of subclinical atherosclerosis: a randomized clinical trial.Prev Med. 2009 Aug-Sep;49(2-3):101-7. doi: 10.1016/j.ypmed.2009.06.018. Epub 2009 Jun 30. Prev Med. 2009. PMID: 19573556 Clinical Trial.
-
Garlic Lowers Blood Pressure in Hypertensive Individuals, Regulates Serum Cholesterol, and Stimulates Immunity: An Updated Meta-analysis and Review.J Nutr. 2016 Feb;146(2):389S-396S. doi: 10.3945/jn.114.202192. Epub 2016 Jan 13. J Nutr. 2016. PMID: 26764326 Review.
-
Mechanisms underlying the antihypertensive effects of garlic bioactives.Nutr Res. 2014 Feb;34(2):106-15. doi: 10.1016/j.nutres.2013.12.005. Epub 2014 Jan 6. Nutr Res. 2014. PMID: 24461311 Review.
Cited by 36 articles
-
S -1-Propenylcysteine, a sulfur compound in aged garlic extract, alleviates cold-induced reduction in peripheral blood flow in rat via activation of the AMPK/eNOS/NO pathway.Exp Ther Med. 2020 Sep;20(3):2815-2821. doi: 10.3892/etm.2020.8969. Epub 2020 Jul 7. Exp Ther Med. 2020. PMID: 32765777 Free PMC article.
-
Neuroprotective mechanisms of S-allyl-L-cysteine in neurological disease.Exp Ther Med. 2020 Feb;19(2):1565-1569. doi: 10.3892/etm.2019.8391. Epub 2019 Dec 27. Exp Ther Med. 2020. PMID: 32010340 Free PMC article. Review.
-
Effects of aged garlic extract on arterial elasticity in a placebo-controlled clinical trial using EndoPAT™ technology.Exp Ther Med. 2020 Feb;19(2):1490-1499. doi: 10.3892/etm.2019.8378. Epub 2019 Dec 27. Exp Ther Med. 2020. PMID: 32010328 Free PMC article.
-
Garlic lowers blood pressure in hypertensive subjects, improves arterial stiffness and gut microbiota: A review and meta-analysis.Exp Ther Med. 2020 Feb;19(2):1472-1478. doi: 10.3892/etm.2019.8374. Epub 2019 Dec 27. Exp Ther Med. 2020. PMID: 32010325 Free PMC article.
-
The Use of Nutraceuticals to Counteract Atherosclerosis: The Role of the Notch Pathway.Oxid Med Cell Longev. 2019 May 2;2019:5470470. doi: 10.1155/2019/5470470. eCollection 2019. Oxid Med Cell Longev. 2019. PMID: 31915510 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
-
Full Text Sources
-
Other Literature Sources
-
Medical