Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension
- PMID: 20448634
- DOI: 10.1038/hr.2010.72
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension
Abstract
Exercise training has an important role in the prevention and treatment of hypertension, but its effects on the early metabolic and hemodynamic abnormalities observed in normotensive offspring of hypertensive parents (FH+) have not been studied. We compared high-intensity interval (aerobic interval training, AIT) and moderate-intensity continuous exercise training (CMT) with regard to hemodynamic, metabolic and hormonal variables in FH+ subjects. Forty-four healthy FH+ women (25.0+/-4.4 years) randomized to control (ConFH+) or to a three times per week equal-volume AIT (80-90% of VO(2MAX)) or CMT (50-60% of VO(2MAX)) regimen, and 15 healthy women with normotensive parents (ConFH-; 25.3+/-3.1 years) had their hemodynamic, metabolic and hormonal variables analyzed at baseline and after 16 weeks of follow-up. Ambulatorial blood pressure (ABP), glucose and cholesterol levels were similar among all groups, but the FH+ groups showed higher insulin, insulin sensitivity, carotid-femoral pulse wave velocity (PWV), norepinephrine and endothelin-1 (ET-1) levels and lower nitrite/nitrate (NOx) levels than ConFH- subjects. AIT and CMT were equally effective in improving ABP (P<0.05), insulin and insulin sensitivity (P<0.001); however, AIT was superior in improving cardiorespiratory fitness (15 vs. 8%; P<0.05), PWV (P<0.01), and BP, norepinephrine, ET-1 and NOx response to exercise (P<0.05). Exercise intensity was an important factor in improving cardiorespiratory fitness and reversing hemodynamic, metabolic and hormonal alterations involved in the pathophysiology of hypertension. These findings may have important implications for the exercise training programs used for the prevention of inherited hypertensive disorder.
Similar articles
-
Haemodynamic, metabolic and neuro-humoral abnormalities in young normotensive women at high familial risk for hypertension.J Hum Hypertens. 2010 Dec;24(12):814-22. doi: 10.1038/jhh.2010.21. Epub 2010 Mar 18. J Hum Hypertens. 2010. PMID: 20237500
-
Heart rate response to exercise and cardiorespiratory fitness of young women at high familial risk for hypertension: effects of interval vs continuous training.Eur J Cardiovasc Prev Rehabil. 2011 Dec;18(6):824-30. doi: 10.1177/1741826711398426. Epub 2011 Feb 28. Eur J Cardiovasc Prev Rehabil. 2011. PMID: 21450597 Clinical Trial.
-
Aerobic interval training reduces blood pressure and improves myocardial function in hypertensive patients.Eur J Prev Cardiol. 2012 Apr;19(2):151-60. doi: 10.1177/1741826711400512. Epub 2011 Mar 4. Eur J Prev Cardiol. 2012. PMID: 21450580 Clinical Trial.
-
Exercise for the management of type 2 diabetes: a review of the evidence.Acta Diabetol. 2010 Mar;47(1):15-22. doi: 10.1007/s00592-009-0126-3. Epub 2009 Jun 3. Acta Diabetol. 2010. PMID: 19495557 Review.
-
Exercise training, lipid regulation, and insulin action: a tangled web of cause and effect.Obesity (Silver Spring). 2009 Dec;17 Suppl 3:S21-6. doi: 10.1038/oby.2009.384. Obesity (Silver Spring). 2009. PMID: 19927141 Review.
Cited by 53 articles
-
Development of Novel Continuous and Interval Exercise Programs by Applying the FITT-VP Principle in Dogs.ScientificWorldJournal. 2020 Apr 13;2020:3029591. doi: 10.1155/2020/3029591. eCollection 2020. ScientificWorldJournal. 2020. PMID: 32327939 Free PMC article.
-
Comparison of Acute Cardiometabolic Responses in a 7-Minute Body Weight Circuit to 7-Minute HIIT Training Protocol.Int J Exerc Sci. 2020 Feb 1;13(2):395-409. eCollection 2020. Int J Exerc Sci. 2020. PMID: 32148625 Free PMC article.
-
Effectiveness of High-Intensity Interval Training Versus Moderate-Intensity Continuous Training in Hypertensive Patients: a Systematic Review and Meta-Analysis.Curr Hypertens Rep. 2020 Mar 3;22(3):26. doi: 10.1007/s11906-020-1030-z. Curr Hypertens Rep. 2020. PMID: 32125550 Review.
-
HIIT is not superior to MICT in altering blood lipids: a systematic review and meta-analysis.BMJ Open Sport Exerc Med. 2019 Dec 17;5(1):e000647. doi: 10.1136/bmjsem-2019-000647. eCollection 2019. BMJ Open Sport Exerc Med. 2019. PMID: 31921439 Free PMC article. Review.
-
Exercise Training as a Treatment for Cardiometabolic Risk in Sedentary Adults: Are Physical Activity Guidelines the Best Way to Improve Cardiometabolic Health? The FIT-AGEING Randomized Controlled Trial.J Clin Med. 2019 Dec 1;8(12):2097. doi: 10.3390/jcm8122097. J Clin Med. 2019. PMID: 31805736 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
-
Full Text Sources
-
Other Literature Sources
-
Medical
-
Miscellaneous