Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
- PMID: 18391963
- DOI: 10.1038/nm1746
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
Abstract
Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11-16 years) developed alpha-synuclein-positive Lewy bodies in grafted neurons. Our observation has key implications for understanding Parkinson's pathogenesis by providing the first evidence, to our knowledge, that the disease can propagate from host to graft cells. However, available data suggest that the majority of grafted cells are functionally unimpaired after a decade, and recipients can still experience long-term symptomatic relief.
Comment in
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Assessing fetal nerve cell grafts in Parkinson's disease.Nat Med. 2008 May;14(5):483-5. doi: 10.1038/nm0508-483. Nat Med. 2008. PMID: 18463652 No abstract available.
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Pathology: The prion principle.Nature. 2016 Oct 27;538(7626):S13-S16. doi: 10.1038/538S13a. Nature. 2016. PMID: 27783578 No abstract available.
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