Phenolic content of virgin olive oil improves ischemic reactive hyperemia in hypercholesterolemic patients
- PMID: 16286173
- DOI: 10.1016/j.jacc.2005.06.078
Phenolic content of virgin olive oil improves ischemic reactive hyperemia in hypercholesterolemic patients
Abstract
Objectives: The goal of this study was to evaluate the effects of the phenolic content of virgin olive oil on endothelial reactivity.
Background: Endothelial-dependent vasodilatation is impaired during the postprandial state, and oxidative stress could play a key role in its development.
Methods: Twenty-one hypercholesterolemic volunteers received two breakfasts, using a randomized sequential crossover design. Both arms received the same olive oil, but one had its phenolic acid content reduced from 400 to 80 ppm. Ischemic reactive hyperemia (IRH) was measured with a laser-Doppler procedure at baseline and 2 h and 4 h after oil intake. Postprandial plasma concentrations of lipid fractions, lipoperoxides (LPO), 8-epi prostaglandin-F(2alpha), and nitrates/nitrites (NO(x)) were obtained at baseline and after 2 h of the fat meal.
Results: The intake of the polyphenol-rich breakfast was associated with an improvement in endothelial function, as well as a greater increase in concentrations of NO(x) (p < 0.001) and a lower increase in LPO (p < 0.005) and 8-epi prostaglandin-F2alpha (p < 0.001) than the ones induced by the low polyphenol fat meal. A positive correlation was found to exist between NO(x) and enhanced endothelial function at the second hour (r = 0.669; p < 0.01). Furthermore, a negative correlation was found between IRH and LPO (r = -0.203; p < 0.05) and 8-epi prostaglandin-F2alpha levels (r = -0.440; p < 0.05).
Conclusions: A meal containing high-phenolic virgin olive oil improves ischemic reactive hyperemia during the postprandial state. This phenomenon might be mediated via reduction in oxidative stress and the increase of nitric oxide metabolites.
Comment in
-
Virgin olive oil and vegetables improve endothelial health.J Am Coll Cardiol. 2006 Jul 18;48(2):413-4; author reply 414-5. doi: 10.1016/j.jacc.2006.04.052. Epub 2006 Jun 22. J Am Coll Cardiol. 2006. PMID: 16843197 No abstract available.
-
Olive oil and ischemic reactive hyperemia in hypercholesterolemic patients.J Am Coll Cardiol. 2006 Jul 18;48(2):414; author reply 414-5. doi: 10.1016/j.jacc.2006.04.051. Epub 2006 Jun 22. J Am Coll Cardiol. 2006. PMID: 16843199 No abstract available.
Similar articles
-
Acute effects of high-fat meals enriched with walnuts or olive oil on postprandial endothelial function.J Am Coll Cardiol. 2006 Oct 17;48(8):1666-71. doi: 10.1016/j.jacc.2006.06.057. Epub 2006 Sep 26. J Am Coll Cardiol. 2006. PMID: 17045905 Clinical Trial.
-
Chronic effects of a high-fat diet enriched with virgin olive oil and a low-fat diet enriched with alpha-linolenic acid on postprandial endothelial function in healthy men.Br J Nutr. 2008 Jul;100(1):159-65. doi: 10.1017/S0007114508888708. Epub 2008 Feb 14. Br J Nutr. 2008. PMID: 18275619 Clinical Trial.
-
Olive oil and ischemic reactive hyperemia in hypercholesterolemic patients.J Am Coll Cardiol. 2006 Jul 18;48(2):414; author reply 414-5. doi: 10.1016/j.jacc.2006.04.051. Epub 2006 Jun 22. J Am Coll Cardiol. 2006. PMID: 16843199 No abstract available.
-
International conference on the healthy effect of virgin olive oil.Eur J Clin Invest. 2005 Jul;35(7):421-4. doi: 10.1111/j.1365-2362.2005.01516.x. Eur J Clin Invest. 2005. PMID: 16008542 Review.
-
The role of virgin olive oil components in the modulation of endothelial function.J Nutr Biochem. 2006 Jul;17(7):429-45. doi: 10.1016/j.jnutbio.2005.11.007. Epub 2005 Dec 12. J Nutr Biochem. 2006. PMID: 16481154 Review.
Cited by 38 articles
-
Is Extra Virgin Olive Oil an Ally for Women's and Men's Cardiovascular Health?Cardiovasc Ther. 2020 Apr 24;2020:6719301. doi: 10.1155/2020/6719301. eCollection 2020. Cardiovasc Ther. 2020. PMID: 32454893 Free PMC article. Review.
-
Assessing Renal Microvascular Reactivity by Laser Speckle-Contrast Imaging in Angiotensin-II-Treated Mice.Int J Nephrol Renovasc Dis. 2020 Mar 27;13:45-51. doi: 10.2147/IJNRD.S240147. eCollection 2020. Int J Nephrol Renovasc Dis. 2020. PMID: 32273746 Free PMC article.
-
Antihypertensive Effects of Virgin Olive Oil (Unfiltered) Low Molecular Weight Peptides with ACE Inhibitory Activity in Spontaneously Hypertensive Rats.Nutrients. 2020 Jan 20;12(1):271. doi: 10.3390/nu12010271. Nutrients. 2020. PMID: 31968696 Free PMC article.
-
The Fluid Aspect of the Mediterranean Diet in the Prevention and Management of Cardiovascular Disease and Diabetes: The Role of Polyphenol Content in Moderate Consumption of Wine and Olive Oil.Nutrients. 2019 Nov 19;11(11):2833. doi: 10.3390/nu11112833. Nutrients. 2019. PMID: 31752333 Free PMC article. Review.
-
Gynura procumbens Standardised Extract Reduces Cholesterol Levels and Modulates Oxidative Status in Postmenopausal Rats Fed with Cholesterol Diet Enriched with Repeatedly Heated Palm Oil.Evid Based Complement Alternat Med. 2019 Sep 23;2019:7246756. doi: 10.1155/2019/7246756. eCollection 2019. Evid Based Complement Alternat Med. 2019. PMID: 31662779 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
-
Full Text Sources
-
Other Literature Sources
-
Medical
-
Miscellaneous