The association between coffee consumption and plasma total homocysteine levels: the "ATTICA" study
- PMID: 15799175
- DOI: 10.1007/s00380-004-0779-3
The association between coffee consumption and plasma total homocysteine levels: the "ATTICA" study
Abstract
The aim of this work was to investigate the association between homocysteine levels and coffee consumption in a sample of cardiovascular disease-free men and women. From May 2001 to December 2002, we randomly enrolled 1514 men and 1528 women, stratified by age and gender, from the greater area of Athens. Blood samples were collected in the fasting state. Among other investigated factors, dietary habits (including coffee consumption in ml per day, adjusted for 28% caffeine containment) were evaluated using a validated food frequency questionnaire. Men consumed higher quantities of coffee compared with women (250 +/- 55 vs 150 +/- 60 ml/day, P = 0.001), while homocysteine values were also higher in men than in women (14.5 +/- 6 vs 10.8 +/- 3.5 micromol/l, P = 0.001). A dose-response relationship of homocysteine levels with coffee consumption was observed (r = 0.10, P = 0.034). In particular, we found that homocysteine levels were 11.2 +/- 5 micromol/l for no consumption, 11.7 +/- 7 micromol/l for <100 ml/day, 12.5 +/- 7 micromol/l for 200-400 ml/day, and 12.7 +/- 4 micromol/l for >500 ml/day consumption (P = 0.018). The observed trend remained significant even after controlling for the interactions between coffee consumption with gender, smoking habits, physical activity status, and eating habits. However, the sole effect of the consumption of filtered coffee on homocysteine levels was significant only in those who consumed more than 500 ml/day (P = 0.043). Although our findings cannot be evidence for causality, they can be the basis for hypotheses about the relation between homocysteine and coffee that can partially explain the mechanisms by which elevated homocysteine levels may influence coronary risk.
Similar articles
-
The association between lifestyle-related factors and plasma homocysteine levels in healthy individuals from the "ATTICA" Study.Int J Cardiol. 2005 Feb 28;98(3):471-7. doi: 10.1016/j.ijcard.2003.12.036. Int J Cardiol. 2005. PMID: 15708182
-
Dietary and other lifestyle correlates of serum folate concentrations in a healthy adult population in Crete, Greece: a cross-sectional study.Nutr J. 2006 Feb 10;5:5. doi: 10.1186/1475-2891-5-5. Nutr J. 2006. PMID: 16472386 Free PMC article.
-
Lifestyle and cardiovascular disease risk factors as determinants of total cysteine in plasma: the Hordaland Homocysteine Study.Am J Clin Nutr. 1999 Dec;70(6):1016-24. doi: 10.1093/ajcn/70.6.1016. Am J Clin Nutr. 1999. PMID: 10584046
-
Plasma homocysteine levels in patients with type 2 diabetes in a Mediterranean population: relation with nutritional and other factors.Nutr Metab Cardiovasc Dis. 2005 Apr;15(2):109-17. doi: 10.1016/j.numecd.2004.01.001. Epub 2005 Apr 13. Nutr Metab Cardiovasc Dis. 2005. PMID: 15871859
-
Heavy coffee consumption and plasma homocysteine: a randomized controlled trial in healthy volunteers.Am J Clin Nutr. 2000 Nov;72(5):1107-10. doi: 10.1093/ajcn/72.5.1107. Am J Clin Nutr. 2000. PMID: 11063436 Clinical Trial.
Cited by 6 articles
-
Combined Effect Of Coffee Consumption And Cigarette Smoking On Serum Levels Of Vitamin B12, Folic Acid, And Lipid Profile In Young Male: A Cross-Sectional Study.Int J Gen Med. 2019 Nov 22;12:421-432. doi: 10.2147/IJGM.S213737. eCollection 2019. Int J Gen Med. 2019. PMID: 31819593 Free PMC article.
-
The Cigarette Smoking, Coffee and Supplements Intake at Students of Sarajevo University.Med Arch. 2019 Apr;73(2):104-108. doi: 10.5455/medarh.2019.73.104-108. Med Arch. 2019. PMID: 31391697 Free PMC article.
-
Association Between Serum Folate Levels and Caffeinated Beverage Consumption in Pregnant Women in Chiba: The Japan Environment and Children's Study.J Epidemiol. 2018 Oct 5;28(10):414-419. doi: 10.2188/jea.JE20170019. Epub 2018 Apr 28. J Epidemiol. 2018. PMID: 29709887 Free PMC article.
-
Cytokines in Schizophrenia: Hope or Hype?Indian J Psychol Med. 2016 Mar-Apr;38(2):97-100. doi: 10.4103/0253-7176.178766. Indian J Psychol Med. 2016. PMID: 27114618 Free PMC article. Review.
-
Current evidence for the use of coffee and caffeine to prevent age-related cognitive decline and Alzheimer's disease.J Nutr Health Aging. 2014 Apr;18(4):383-92. doi: 10.1007/s12603-014-0021-7. J Nutr Health Aging. 2014. PMID: 24676319 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
-
Full Text Sources
-
Other Literature Sources
-
Medical