Downregulation of cerebrospinal fluid production in patients with chronic hydrocephalus
- PMID: 12507122
- DOI: 10.3171/jns.2002.97.6.1271
Downregulation of cerebrospinal fluid production in patients with chronic hydrocephalus
Abstract
Object: The goal of this study was to determine the effect of hydrocephalus on cerebrospinal fluid (CSF) production rates in patients with acute and chronic hydrocephalus.
Methods: The authors studied CSF production both in patients presenting with acute and chronic hydrocephalus, and patients with Parkinson disease (PD) of a similar mean age, whose CSF production was known to be normal. A modification of the Masserman method was used to measure CSF production through a ventricular catheter. The CSF production rates (means +/- standard deviations) in the three groups were then compared. The patients with PD had a mean CSF production rate of 0.42 +/- 0.13 ml/minute; this value lies within the normal range measured using this technique. Patients with acute hydrocephalus had a similar CSF production rate of 0.4 +/- 0.13 ml/minute, whereas patients with chronic hydrocephalus had a significantly decreased mean CSF production rate of 0.25 +/- 0.08 ml/minute.
Conclusions: The authors postulate that chronic increased intracranial pressure causes downregulation of CSF production.
Comment in
-
Cerebrospinal fluid production.J Neurosurg. 2003 Jul;99(1):206-7; author reply 207. doi: 10.3171/jns.2003.99.1.0206. J Neurosurg. 2003. PMID: 12854768 No abstract available.
-
Normal-pressure hydrocephalus and Alzheimer disease.J Neurosurg. 2003 Oct;99(4):797-8; author reply 798-9. doi: 10.3171/jns.2003.99.4.0797. J Neurosurg. 2003. PMID: 14567622 No abstract available.
Similar articles
-
VEGF/VEGFR-2 changes in frontal cortex, choroid plexus, and CSF after chronic obstructive hydrocephalus.J Neurol Sci. 2010 Sep 15;296(1-2):39-46. doi: 10.1016/j.jns.2010.06.012. J Neurol Sci. 2010. PMID: 20619858 Free PMC article.
-
Evaluation of cerebrospinal fluid production in the development of communicating hydrocephalus.Radiology. 1977 Jan;122(1):143-7. doi: 10.1148/122.1.143. Radiology. 1977. PMID: 830324
-
Age dependence of cerebrospinal pressure-volume compensation in patients with hydrocephalus.J Neurosurg. 2001 Mar;94(3):482-6. doi: 10.3171/jns.2001.94.3.0482. J Neurosurg. 2001. PMID: 11235954
-
Idiopathic cerebrospinal fluid overproduction: case-based review of the pathophysiological mechanism implied in the cerebrospinal fluid production.Croat Med J. 2014 Aug 28;55(4):377-87. doi: 10.3325/cmj.2014.55.377. Croat Med J. 2014. PMID: 25165051 Free PMC article. Review.
-
[Production and absorption of the cerebrospinal fluid (author's transl)].No To Shinkei. 1981 Sep;33(9):911-26. No To Shinkei. 1981. PMID: 7032548 Review. Japanese. No abstract available.
Cited by 18 articles
-
Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets.Nat Rev Neurol. 2020 May;16(5):285-296. doi: 10.1038/s41582-020-0321-y. Epub 2020 Mar 9. Nat Rev Neurol. 2020. PMID: 32152460 Review.
-
Cerebrospinal fluid volumetric net flow rate and direction in idiopathic normal pressure hydrocephalus.Neuroimage Clin. 2018;20:731-741. doi: 10.1016/j.nicl.2018.09.006. Epub 2018 Sep 14. Neuroimage Clin. 2018. PMID: 30238917 Free PMC article.
-
Comparative transcriptomics of choroid plexus in Alzheimer's disease, frontotemporal dementia and Huntington's disease: implications for CSF homeostasis.Fluids Barriers CNS. 2018 May 31;15(1):18. doi: 10.1186/s12987-018-0102-9. Fluids Barriers CNS. 2018. PMID: 29848382 Free PMC article.
-
Aging alters mRNA expression of amyloid transporter genes at the blood-brain barrier.Neurobiol Aging. 2017 Sep;57:178-185. doi: 10.1016/j.neurobiolaging.2017.05.011. Epub 2017 May 19. Neurobiol Aging. 2017. PMID: 28654861 Free PMC article.
-
Intracranial Pressure and Its Relationship to Glaucoma: Current Understanding and Future Directions.Med Hypothesis Discov Innov Ophthalmol. 2015 Fall;4(3):71-80. Med Hypothesis Discov Innov Ophthalmol. 2015. PMID: 27350948 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
-
Full Text Sources
-
Other Literature Sources
-
Medical