Serum cleaved tau protein levels and clinical outcome in adult patients with closed head injury
- PMID: 11867977
- DOI: 10.1067/mem.2002.121214
Serum cleaved tau protein levels and clinical outcome in adult patients with closed head injury
Abstract
Study objective: Intracranial injuries (ICI) are associated with high mortality and morbidity. Unfortunately, tools for diagnosis and risk stratification of ICIs are limited in the emergency department setting. We determine the relationship between the presence or absence of a detectable cleaved serum tau protein (tau(c)), ICI, and outcome at hospital discharge in adults with closed head injuries (CHI).
Methods: This was a prospective pilot study of adult patients with CHI presenting to the ED of an urban Level I trauma center. Patients presenting within 10 hours of a CHI who underwent a head computed tomographic (CT) scan were eligible. A blood sample was collected at presentation and the tau(c) level was measured. Initial Glasgow Coma Scale scores and demographic information were recorded. A chart review was performed to determine outcome and final readings on the initial head CT scan.
Results: Patients were dichotomized to 1 of 2 groups, those with an ICI (n=17) and those with an isolated skull fracture or no CT abnormality (NICI) (n=11). The 2 groups were similar in regard to demographic composition, mechanism of injury, and coexisting injuries. A tau(c) level of more than 0 was associated with an increased chance of an ICI on the initial head CT scan (odds ratio 11.25; 95% confidence interval [CI] 1.17 to 108.4) and a greater chance of poor outcome, defined as death while in hospital or transfer to a nursing home at hospital discharge (odds ratio 8.17; 95% CI 1.42 to 47).
Conclusion: A tau(c) level of more than 0 is associated with a greater chance of intracranial injury and poor outcome in patients with CHI.
Comment in
-
Rule out TBI? Serum markers for traumatic brain injury.Ann Emerg Med. 2002 Mar;39(3):342-3. doi: 10.1067/mem.2002.122007. Ann Emerg Med. 2002. PMID: 11867995 No abstract available.
Similar articles
-
Performance of Glial Fibrillary Acidic Protein in Detecting Traumatic Intracranial Lesions on Computed Tomography in Children and Youth With Mild Head Trauma.Acad Emerg Med. 2015 Nov;22(11):1274-82. doi: 10.1111/acem.12795. Epub 2015 Oct 15. Acad Emerg Med. 2015. PMID: 26469937 Free PMC article. Clinical Trial.
-
Relationship of serum S100B levels and intracranial injury in children with closed head trauma.Pediatrics. 2009 Oct;124(4):e697-704. doi: 10.1542/peds.2008-1493. Epub 2009 Sep 28. Pediatrics. 2009. PMID: 19786430
-
Pediatric minor head trauma: indications for computed tomographic scanning revisited.J Trauma. 2001 Aug;51(2):231-7; discussion 237-8. doi: 10.1097/00005373-200108000-00004. J Trauma. 2001. PMID: 11493779
-
Diagnostic management strategies for adults and children with minor head injury: a systematic review and an economic evaluation.Health Technol Assess. 2011 Aug;15(27):1-202. doi: 10.3310/hta15270. Health Technol Assess. 2011. PMID: 21806873 Free PMC article. Review.
-
[Value of serial CT scanning and intracranial pressure monitoring for detecting new intracranial mass effect in severe head injury patients showing lesions type I-II in the initial CT scan].Neurocirugia (Astur). 2005 Jun;16(3):217-34. Neurocirugia (Astur). 2005. PMID: 16007322 Review. Spanish.
Cited by 19 articles
-
High Serum Levels of Serum 100 Beta Protein, Neuron-specific Enolase, Tau, Active Caspase-3, M30 and M65 in Children with Autism Spectrum Disorders.Clin Psychopharmacol Neurosci. 2020 May 31;18(2):270-278. doi: 10.9758/cpn.2020.18.2.270. Clin Psychopharmacol Neurosci. 2020. PMID: 32329316 Free PMC article.
-
The prognostic value of the Tau protein serum level in metastatic breast cancer patients and its correlation with brain metastases.BMC Cancer. 2019 Jan 30;19(1):110. doi: 10.1186/s12885-019-5287-z. BMC Cancer. 2019. PMID: 30700265 Free PMC article.
-
MicroRNAs as diagnostic markers and therapeutic targets for traumatic brain injury.Neural Regen Res. 2017 Nov;12(11):1749-1761. doi: 10.4103/1673-5374.219025. Neural Regen Res. 2017. PMID: 29239310 Free PMC article. Review.
-
Review of the potential use of blood neuro-biomarkers in the diagnosis of mild traumatic brain injury.Clin Exp Emerg Med. 2017 Sep 30;4(3):121-127. doi: 10.15441/ceem.17.226. eCollection 2017 Sep. Clin Exp Emerg Med. 2017. PMID: 29026884 Free PMC article. Review.
-
Potential Blood-based Biomarkers for Concussion.Sports Med Arthrosc Rev. 2016 Sep;24(3):108-15. doi: 10.1097/JSA.0000000000000117. Sports Med Arthrosc Rev. 2016. PMID: 27482776 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
-
Full Text Sources
-
Other Literature Sources
-
Medical