Plausible mechanisms for the protectiveness of whole grains
- PMID: 10479218
- DOI: 10.1093/ajcn/70.3.459s
Plausible mechanisms for the protectiveness of whole grains
Abstract
Dietary guidelines recommend the consumption of whole grains to prevent chronic diseases. Epidemiologic studies support the theory that whole grains are protective against cancer, especially gastrointestinal cancers such as gastric and colon can-cer, and cardiovascular disease. Components in whole grains that may be protective include compounds that affect the gut environment, such as dietary fiber, resistant starch, and oligosaccharides. Whole grains are also rich in compounds that function as antioxidants, such as trace minerals and phenolic compounds, and phytoestrogens, with potential hormonal effects. Other potential mechanisms whereby whole grains may protect against disease include binding of carcinogens and modulation of the glycemic response. Clearly, the range of protective substances in whole grains is impressive and advice to consume additional whole grains is justified. Further study is needed regarding the mechanisms behind this protection so that the most potent protective components of whole grains will be maintained when developing whole grains into acceptable food products for the public.
Similar articles
-
Whole-grain consumption and chronic disease: protective mechanisms.Nutr Cancer. 1997;27(1):14-21. doi: 10.1080/01635589709514495. Nutr Cancer. 1997. PMID: 8970176 Review.
-
Mechanisms for the impact of whole grain foods on cancer risk.J Am Coll Nutr. 2000 Jun;19(3 Suppl):300S-307S. doi: 10.1080/07315724.2000.10718964. J Am Coll Nutr. 2000. PMID: 10875601 Review.
-
Epidemiological evidence for the impact of whole grains on health.Crit Rev Food Sci Nutr. 1994;34(5-6):427-34. doi: 10.1080/10408399409527672. Crit Rev Food Sci Nutr. 1994. PMID: 7811375 Review.
-
Grain processing and nutrition.Crit Rev Food Sci Nutr. 2000 Jul;40(4):309-26. doi: 10.1080/10408690091189176. Crit Rev Food Sci Nutr. 2000. PMID: 10943592
-
Why whole grains are protective: biological mechanisms.Proc Nutr Soc. 2003 Feb;62(1):129-34. doi: 10.1079/PNS2002221. Proc Nutr Soc. 2003. PMID: 12740067 Review.
Cited by 70 articles
-
Food groups, diet quality and colorectal cancer risk in the Basque Country.World J Gastroenterol. 2020 Jul 28;26(28):4108-4125. doi: 10.3748/wjg.v26.i28.4108. World J Gastroenterol. 2020. PMID: 32821073 Free PMC article.
-
Whole grain food diet slightly reduces cardiovascular risks in obese/overweight adults: a systematic review and meta-analysis.BMC Cardiovasc Disord. 2020 Feb 18;20(1):82. doi: 10.1186/s12872-020-01337-z. BMC Cardiovasc Disord. 2020. PMID: 32070285 Free PMC article.
-
Plant Foods, Antioxidant Biomarkers, and the Risk of Cardiovascular Disease, Cancer, and Mortality: A Review of the Evidence.Adv Nutr. 2019 Nov 1;10(Suppl_4):S404-S421. doi: 10.1093/advances/nmz042. Adv Nutr. 2019. PMID: 31728499
-
Utilization of Fermented Rice Milk as a Novel Coagulant for Development of Paneer (Soft Cheese).Foods. 2019 Aug 12;8(8):339. doi: 10.3390/foods8080339. Foods. 2019. PMID: 31408978 Free PMC article.
-
Metabolic Effects of Resistant Starch Type 2: A Systematic Literature Review and Meta-Analysis of Randomized Controlled Trials.Nutrients. 2019 Aug 8;11(8):1833. doi: 10.3390/nu11081833. Nutrients. 2019. PMID: 31398841 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
-
Full Text Sources
-
Other Literature Sources
-
Medical