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Gut. 1990 Apr; 31(4): 450–453.
PMCID: PMC1378422
PMID: 2338272

Effect of coffee on distal colon function.

S R Brown, P A Cann, and N W Read
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Abstract

Ninety nine healthy young volunteers (58 men, 34 women, aged 17-27 years) answered a questionnaire concerning their bowel habit with particular reference to the effects of beverages. Twenty nine per cent (63% women) claimed that coffee induced a desire to defecate. The rectosigmoid motor responses to black, unsweetened coffee were then investigated by multiport manometry in 14 healthy-subjects (12 men, two women, eight of whom claimed coffee caused a desire to defecate (responders). Results revealed an increase in motility index within four minutes after ingestion of both regular and decaffeinated coffee (p less than 0.05) in the eight responders, but not in the six non-responders. The increase in rectosigmoid motility induced by coffee lasted at least 30 minutes. There was no increase in the motility index in any subject after a drink of hot water. These results suggest that drinking coffee can stimulate a motor response of the distal colon in some normal people.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Dennish GW, Castell DO. Caffeine and the lower esophageal sphincter. Am J Dig Dis. 1972 Nov;17(11):993–996. [PubMed] [Google Scholar]
  • Debas HT, Cohen MM, Holubitsky IB, Harrison RC. Caffeine-stimulated acid and pepsin secretion: dose-response studies. Scand J Gastroenterol. 1971;6(5):453–457. [PubMed] [Google Scholar]
  • Wald A, Back C, Bayless TM. Effect of caffeine on the human small intestine. Gastroenterology. 1976 Nov;71(5):738–742. [PubMed] [Google Scholar]
  • Read NW. Irritable bowel syndrome (IBS)--definition and pathophysiology. Scand J Gastroenterol Suppl. 1987;130:7–13. [PubMed] [Google Scholar]
  • Acquaviva F, DeFrancesco A, Andriulli A, Piantino P, Arrigoni A, Massarenti P, Balzola F. Effect of regular and decaffeinated coffee on serum gastrin levels. J Clin Gastroenterol. 1986 Apr;8(2):150–153. [PubMed] [Google Scholar]
  • Snape WJ, Jr, Matarazzo SA, Cohen S. Effect of eating and gastrointestinal hormones on human colonic myoelectrical and motor activity. Gastroenterology. 1978 Sep;75(3):373–378. [PubMed] [Google Scholar]
  • Renny A, Snape WJ, Jr, Sun EA, London R, Cohen S. Role of cholecystokinin in the gastrocolonic response to a fat meal. Gastroenterology. 1983 Jul;85(1):17–21. [PubMed] [Google Scholar]
  • Boublik JH, Quinn MJ, Clements JA, Herington AC, Wynne KN, Funder JW. Coffee contains potent opiate receptor binding activity. Nature. 1983 Jan 20;301(5897):246–248. [PubMed] [Google Scholar]
  • Bueno L, Fioramonti J, Hondé C, Fargeas MJ, Primi MP. Central and peripheral control of gastrointestinal and colonic motility by endogenous opiates in conscious dogs. Gastroenterology. 1985 Feb;88(2):549–556. [PubMed] [Google Scholar]
  • Sun EA, Snape WJ, Jr, Cohen S, Renny A. The role of opiate receptors and cholinergic neurons in the gastrocolonic response. Gastroenterology. 1982 Apr;82(4):689–693. [PubMed] [Google Scholar]

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