Hempseed as a nutritional resource: An overview

Summary

The seed of Cannabis sativa L. has been an important source of nutrition for thousands of years in Old World cultures. Non-drug varieties of Cannabis, commonly referred to as hemp, have not been studied extensively for their nutritional potential in recent years, nor has hempseed been utilized to any great extent by the industrial processes and food markets that have developed during the 20th century. Technically a nut, hempseed typically contains over 30% oil and about 25% protein, with considerable amounts of dietary fiber, vitamins and minerals. Hempseed oil is over 80% in polyunsaturated fatty acids (PUFAs), and is an exceptionally rich source of the two essential fatty acids (EFAs) linoleic acid (18:2 omega-6) and alpha-linolenic acid (18:3 omega-3). The omega-6 to omega-3 ratio (n6/n3) in hempseed oil is normally between 2:1 and 3:1, which is considered to be optimal for human health. In addition, the biological metabolites of the two EFAs, gamma-linolenic acid (18:3 omega-6; ‘GLA’) and stearidonic acid (18:4 omega-3; ‘SDA’), are also present in hempseed oil. The two main proteins in hempseed are edestin and albumin. Both of these high-quality storage proteins are easily digested and contain nutritionally significant amounts of all essential amino acids. In addition, hempseed has exceptionally high levels of the amino acid arginine. Hempseed has been used to treat various disorders for thousands of years in traditional oriental medicine. Recent clinical trials have identified hempseed oil as a functional food, and animal feeding studies demonstrate the long-standing utility of hempseed as an important food resource.

This is a preview of subscription content, log in to check access.

References

  1. Anes, E., M.P. Kühnel, E. Bos, J. Moniz-Pereira, A. Habermann & G. Griffiths, 2003. Selected lipids activate phagosome actin assembly and maturation resulting in killing of pathogenic mycobacteria. Nature Cell Biol 5(9): 793–802.

    PubMed  CAS  Google Scholar 

  2. Barre, D.E., 2001. Potential of evening primrose, borage, black currant, and fungal oils in human health. Ann Nutr Metab 45: 47– 57.

    PubMed  CAS  Google Scholar 

  3. Burr, G.O. & M.M. Burr, 1929. New deficiency disease produced by the rigid exclusion of fat from the diet. J Biol Chem 82: 345– 367.

    CAS  Google Scholar 

  4. Burr, G.O. & M.M. Burr, 1930. On the nature and role of fatty acids essential to nutrition. J Biol Chem 86: 587–621.

    CAS  Google Scholar 

  5. Bordoni, A., P.L. Biagi, M. Masi, G. Ricci, C. Fanelli, A. Patrizi & E. Ceccolini, 1988. Evening primrose oil (Efamol) in the treatment of children with atopic dermatitis. Drugs Exp Clin Res 14(4): 291–297.

    PubMed  CAS  Google Scholar 

  6. Callaway, J.C., U. Schwab, I. Harvima, P. Halonen, O. Mykkänen, P. Hyvönen & T. Järvinen, 2004. Efficacy of dietary hempseed oil on plasma lipids and skin quality in patients with atopic dermatitis. J Derm Treat (submitted).

  7. Callaway, J.C., 2002. Hemp as food at high latitudes. J Ind Hemp 7(1): 105–117.

    Google Scholar 

  8. Callaway, J.C., T. Tennilä & D.W. Pate, 1997a. Occurrence of “omega-3” stearidonic acid (cis-6,9,12,15-octadecatetraenoic acid) in hemp (Cannabis sativa L.) seed. J Int Hemp Assoc 3: 61–63.

    Google Scholar 

  9. Callaway, J.C., R.A. Weeks, L.P. Raymon, H.C. Walls & W.L. Hearn, 1997b. A positive Urinalysis from hemp (Cannabis) seed oil. J Anal Toxicol 21(4): 319–320.

    CAS  Google Scholar 

  10. Callaway, J.C. & T.T. Laakkonen, 1996. Cultivation of Cannabis oil seed varieties in Finland. J Int Hemp Assoc 3(1): 32–34.

    Google Scholar 

  11. Callow J., L.K. Summers, H. Bradshaw & K.N. Frayn, 2002. Changes in LDL particle composition after the consumption of meals containing different amounts and types of fat. Am J Clin Nutr 76(2): 345–350.

    PubMed  CAS  Google Scholar 

  12. Coghlan, A., 2003. Right kind of fat gives body the edge over TB. New Scientist, August: 12.

  13. Darshan, S.K. & I.L. Rudolph, 2000. Effect of fatty acids of w-6 and w-3 type on human immune status and role of eicosanoids. Nutrition 16: 143–145.

    Google Scholar 

  14. Deferne, J.L. & D.W. Pate, 1996. Hemp seed oil: A source of valuable essential fatty acids. J Int Hemp Assoc 3(1): 1–7.

    Google Scholar 

  15. de Padua, L.S., N. Bunyaprafatsara & R.H.M.J. Lemmens (Eds.), 1999. Plant Resources of South-East Asia: Medicinal and Poisonous Plants, Vol. 1, No. 12, pp. 167–175. Backhuys Publishers, Leiden.

    Google Scholar 

  16. Derek, J.R. & K.A. Meckling-Gill, 1999. Both (n-3) and (n-6) fatty acids stimulate wound healing in the rat intestine epithelial cell line, IEC-6. Am Soc Nutr Sci 129: 1791–1798.

    Google Scholar 

  17. Gerster, H., 1988. Can adults adequately convert alpha-linolenic acid (18:3n-3) to eicosapentanoic acid (20:5n-3) and docosahexanoic acid (22:6n-3)? Int J Vit Nutr Res 68: 159–173.

    Google Scholar 

  18. Grigoriev, O.V., 2002. Application of hempseed (Cannabis sativa L.) oil in the treatment of the ear, nose and throat (ENT) disorders. J Ind Hemp 7(2): 5–15.

    CAS  Google Scholar 

  19. Hampson, A.J., M. Grimaldi, M. Lolic, D. Wink, R. Rosenthal, J. Axelrod, 2000. Neuroprotective antioxidants from marijuana. Ann N Y Acad Sci 899: 274–282.

    PubMed  CAS  Article  Google Scholar 

  20. Harbige, L.S. & B.A.C. Fisher, 2001. Dietary fatty acid modulation of mucosally-induced tolerogenic immune response. Proc Nutr Soc 60: 449–456.

    Article  PubMed  CAS  Google Scholar 

  21. Harbige, L.S., L. Layward & M.M. Morris-Downes, 2000. The protective effects of omega-6 fatty acids in experimental autoimmune encephalomyelitis (EAE) in relation to transforming growth factor-beta 1 (TGF-β 1) up-regulation and increased prostaglandin E2 (PGE2) production. Clin Exp Immunol 122: 445–452.

    Article  CAS  PubMed  Google Scholar 

  22. Horrobin, D.F., 2000. Essential fatty acid metabolism and its modification in atopic eczema. Am J Clin Nutr 71(1): 367– 72S.

    Google Scholar 

  23. Kassirer, J.P., 1997. Federal foolishness. New Engl J Med 30: 366.

    Google Scholar 

  24. Kriese, U., E. Schumann, W.E. Weber, M. Beyer, L. Brühl & B. Matthäus, 2004. Oil content, tocopherol composition and fatty acid patterns of the seeds of 51 Cannabis sativa L. genotypes. Euphytica 137: 339–351.

    CAS  Google Scholar 

  25. Laakkonen, T.T. & J.C. Callaway, 1998. Update on FIN-314. J Int Hemp Assoc 5(1): 34–35.

    Google Scholar 

  26. G. Leson, P. Pless, J.W. Roulac, (Eds.), 1999. Hemp Foods & Oils for Health, 2nd edn. Hemptech, Ltd, Sebastopol.

    Google Scholar 

  27. Leson, G., P. Pless, F. Grotenhermen, H. Kalant & M.A. ElSohly, 2001. Evaluating the impact of hemp food consumption on workplace drug tests. J Anal Toxicol 25(8): 691–698.

    PubMed  CAS  Google Scholar 

  28. McPartland, M.J. & G. Geoffrey, 2004. Random queries concerning the evolution of Cannabis and coevolution with the cannabinoid receptor. In: G. Guy, R. Robson, K. Strong, B. Whittle, (Eds.), The Medicinal Use of Cannabis, pp. 71–102. Royal Society of Pharmacists, London.

    Google Scholar 

  29. Manku, M.S., D.F. Horribin, N. Morse, V. Kyte, K. Jenkins, S. Wright & J.L. Burton, 1982. Reduced levels of prostaglandin precursors in the blood of atopic patients; defective delta-6-desaturase function as a biochemical basis for atopy. Prostaglandins Leukot Med 9(6): 615–628.

    PubMed  CAS  Google Scholar 

  30. Manku, M.S., D.F. Horrobin, N.L. Morse, S. Wright & J.L. Burton, 1984. Essential fatty acids in the plasma phospholipids of patients with atopic eczema. Br J Dermatol 110(6): 643–648.

    PubMed  CAS  Google Scholar 

  31. Mechoulam, R., 1986. Cannabinoids as therapeutic agents, pp. 1–20. CRC Press, Boca Raton.

    Google Scholar 

  32. Mechoulam, R. & L. Hanu, 2001. The cannabinoids: An overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection. Pain Res Manage 6(2): 67–73.

    CAS  Google Scholar 

  33. Mechoulam, R., D. Panikashvili & E. Shohami, 2002. Cannabinoids and brain injury: Therapeutic implications. Trends Mol Med 8(2): 58–61.

    PubMed  CAS  Google Scholar 

  34. Mustafa, A.F., J.J. McKinnon & D.A. Christensen, 1999. The nutritive value of hemp meal for ruminants. Can J Anim Sci 79(1): 91–95.

    Article  Google Scholar 

  35. Ngeh-Ngwainbi, J., J. Lin & A. Chandler, 1997. Determination of total, saturated, unsaturated, and monounsaturated fats in cereal products by acid hydrolysis and capillary gas chromatography: Collaborative study. J AOAC Int 80(2): 359–372.

    PubMed  CAS  Google Scholar 

  36. Odani, S. & S. Odani, 1998. Isolation and primary structure of a methionine and cystine-rich seed protein of Cannabis sativa L. Biosci Biotechnol Biochem, 62: 650–654.

    PubMed  CAS  Google Scholar 

  37. Okuyama, H., T. Kobayashi & S. Watanabe, 1997. Dietary fatty acids- the N-6/N-3 balance and chronic elderly diseases. Excess linoleic acid and relative N-3 deficiency syndrome seen in Japan. Prog Lipid Res 3: 409–457.

    Google Scholar 

  38. Oliwiecki, S., J.L. Burton, K. Elles & D.F. Horrobin, 1991. Levels of essential and other fatty acids in plasma red cell phospholipids from normal controls and patients with atopic eczema. Acta Derm Venereol 71(3): 224–228.

    PubMed  CAS  Google Scholar 

  39. Pringle, H., 1997. Ice age community may be earliest known net hunters. Science 277: 1203–1204.

    CAS  Google Scholar 

  40. Russell, D., 2003. Phagosomes, fatty acids and tuberculosis. Nature Cell Bio 5(9): 776–778.

    CAS  Google Scholar 

  41. Sakai, K., H. Okuyama, H. Shimazaki, M. Katagiri, S. Torii, T. Matsushita & S. Baba, 1994. Fatty acid compositions of plasma lipids in atopic dermatitis/asthma patients. Arerugi 43(1): 37– 43.

    PubMed  CAS  Google Scholar 

  42. H. Scherz, G. Kloos, F. Senser, (Eds.), 1986. Food Composition and Nutrition Tables 1986/1987, 3rd edn. Wissenschaftliche Veriagsgesellschaft mbH, Stuttgart.

    Google Scholar 

  43. Silversides, F.G., K.L. Budgell & M.R. Lefrançois, 2002. Effect of feeding hemp seed meal to laying hens. Atlantic Poultry Research Institute; APRI Factsheet 16: 2 pp.

    Google Scholar 

  44. Simopoulos, A.P., 1991. Omega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr 54: 438–463.

    PubMed  CAS  Google Scholar 

  45. Simopoulos, A.P., 1999. Essential fatty acids in health and chronic disease. Am J Clin Nutr 70: 560–569.

    Google Scholar 

  46. Simopoulos, A.P., A. Leaf & N. Salem, 2000. Workshop statement on the essentiality of and recommended dietary intakes from omega-6 and omega-3 fatty acids. Prostaglandins Leukot Essent Fatty Acids 63(3): 119–121.

    PubMed  CAS  Google Scholar 

  47. Simopoulos, A.P., 2002a. The importance of the omega-6/omega-3 essential fatty acids. Biomed Pharmacother 56(8): 365–379.

    CAS  Google Scholar 

  48. Simopoulos, A.P., 2002b. Omega-3 fatty acids in inflammation and autoimmune disease. J Am Coll Nutr 21(6): 495–505.

    CAS  Google Scholar 

  49. Sirek, J., 1955. Vyznam konopného semence therapii tuberkulosy (Hempseed in the treatment of tuberculosis). Acta Universitatis Palackianae Olomucensis 6: 1–13.

    Google Scholar 

  50. Small, E. & D. Marcus, 2003. Tetrahydrocannabinol levels in hemp (Cannabis sativa) germplasm resources. Econ Bot 57(4): 545–558.

    CAS  Google Scholar 

  51. Takwale A., E. Tan, S. Agarwall, G. Barclay, I. Ahmed, K. Hotchkiss, J.R. Thompson, T. Chapman & J. Berth-Jones, 2003. Efficacy and tolerability of borage oil in adults and children with atopic eczema: Randomised, double blind, placebo controlled, parallel group trial. Br Med J 327(7428): 1358–1359.

    Google Scholar 

  52. van Gool C.J., C. Thijs, C.J. Henquet, A.D. van Houwelingen, P.C. Dagnelie, J. Schrander, P.P. Menheere & P.A. van den brandt, 2003. gamma-Linolenic acid supplementation for prophylaxis of atopic dermatitis- a randomized controlled trial in infants at high familial risk. Am J Clin Nutr 77: 943–951.

    PubMed  CAS  Google Scholar 

  53. Whitaker, D.K., J. Chilliers & C. de Beer, 1996. Evening primrose (Epogam) in the treatment of chronic hand dermatitis; disappointing therapeutic results. Dermatology 193(2): 115–120.

    PubMed  CAS  Article  Google Scholar 

  54. WHO & FAO Joint Expert Consultation Report, 1995: Fats and oils in human nutrition. Nutr Rev 53(7): 202–205.

    Google Scholar 

  55. Wu, D., M. Meydani, L.S. Leka, Z. Nightingale, G.J. Handelman, J.B. Blumberg & S.N. Meydani, 1999. Effect of dietary supplementation with black currant seed oil on the immune response of healthy elderly subjects. Am J Clin Nutr 70: 536–543.

    PubMed  CAS  Google Scholar 

  56. Xiaozhai, L. & R.C. Clarke, 1995. The cultivation and use of hemp (Cannabis sativa L.) in ancient China. J Int Hemp Assoc 2(1): 26–33.

    Google Scholar 

  57. Yu, G. & B. Björkstén, 1998. Polyunsaturated fatty acids in school children in relation to allergy and serum IgE levels. Pediatr Allergy Immunol 9: 133–138.

    PubMed  CAS  Google Scholar 

  58. Weiss, E., W. Wetterstrom, D. Nadel, O. Bar-Yosef, 2004. The broad spectrum revisted: Evidence from plant remains. Proc Natl Acad Sci USA 101(26): 9551–9555.

    PubMed  CAS  Google Scholar 

  59. Zias, J., H. Stark, J. Sellgman, R. Levy, E. Werker, A. Breuer & R. Mechoulam, 1993. Early medical use of cannabis. Nature 363(6426): 215.

    PubMed  CAS  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to J. C. Callaway.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Callaway, J.C. Hempseed as a nutritional resource: An overview. Euphytica 140, 65–72 (2004). https://doi.org/10.1007/s10681-004-4811-6

Download citation

Key words

  • Cannabis
  • food
  • hemp
  • oil
  • protein
  • seed