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Downregulation of cerebrospinal fluid production in patients with chronic hydrocephalus

Gerald D. Silverberg M.D. 1 , Stephen Huhn M.D. 1 , Richard A. Jaffe M.D., Ph.D. 1 , Steven D. Chang M.D. 1 , Thomas Saul 1 , Gary Heit M.D., Ph.D. 1 , Ann Von Essen B.S. 1 and Edward Rubenstein M.D. 1
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  • 1 Departments of Neurosurgery, Anesthesia, and Medicine, Stanford University School of Medicine, Stanford, California
DOI:
https://doi.org/10.3171/jns.2002.97.6.1271
Online Publication Date:
Dec 2002
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Object. The goal of this study was to determine the effect of hydrocephalus on cerebrospinal fluid (CSF) production rates in patients with acute and chronic hydrocephalus.

Methods. The authors studied CSF production both in patients presenting with acute and chronic hydrocephalus, and patients with Parkinson disease (PD) of a similar mean age, whose CSF production was known to be normal. A modification of the Masserman method was used to measure CSF production through a ventricular catheter. The CSF production rates (means ± standard deviations) in the three groups were then compared.

The patients with PD had a mean CSF production rate of 0.42 ± 0.13 ml/minute; this value lies within the normal range measured using this technique. Patients with acute hydrocephalus had a similar CSF production rate of 0.4 ± 0.13 ml/minute, whereas patients with chronic hydrocephalus had a significantly decreased mean CSF production rate of 0.25 ± 0.08 ml/minute.

Conclusions. The authors postulate that chronic increased intracranial pressure causes downregulation of CSF production.

Volume 97: Issue 6 (Dec 2002)

in Journal of Neurosurgery

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Volume 97: Issue 6

Contributor Notes

Address reprint requests to: Gerald D. Silverberg, M.D., Department of Neurosurgery L233, Stanford University Medical Center, 300 Pasteur Drive, Stanford, California 94305. email: geralds@leland.stanford.edu.
Keywords:
cerebrospinal fluid; hydrocephalus
Page Count:
1271–1275
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