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Table 3.

Coffee consumption and plasma tHcy concentrations.1

Coffee, cups/day All Men Women
Plasma concentration2 Difference Plasma concentration2 Difference Plasma concentration2 Difference
% % of SD % % of SD % % of SD
tHcy, μmol/L  0  10.1  Ref  Ref  10.7  Ref  Ref  9.5  Ref  Ref 
  1–3  10.4  3.5  12.0  11.0  2.5  9.3  9.9  4.5  15.5 
  ≥4  10.8  6.8  23.3  11.2  5.1  18.6  10.3  8.8  29.5 
P for trend (ANCOVA)    <0.001      <0.001      <0.001     
tHcy after adjustment for folate, μmol/L  0  10.3  Ref  Ref  10.9  Ref  Ref  9.8  Ref  Ref 
  1–3  10.5  1.8  6.4  11.0  1.3  4.8  10.0  2.4  8.4 
  ≥4  10.7  3.9  13.4  11.3  2.7  10.0  10.3  5.1  17.6 
P for trend (ANCOVA)    <0.001      0.01      <0.001     
Coffee, cups/day All Men Women
Plasma concentration2 Difference Plasma concentration2 Difference Plasma concentration2 Difference
% % of SD % % of SD % % of SD
tHcy, μmol/L  0  10.1  Ref  Ref  10.7  Ref  Ref  9.5  Ref  Ref 
  1–3  10.4  3.5  12.0  11.0  2.5  9.3  9.9  4.5  15.5 
  ≥4  10.8  6.8  23.3  11.2  5.1  18.6  10.3  8.8  29.5 
P for trend (ANCOVA)    <0.001      <0.001      <0.001     
tHcy after adjustment for folate, μmol/L  0  10.3  Ref  Ref  10.9  Ref  Ref  9.8  Ref  Ref 
  1–3  10.5  1.8  6.4  11.0  1.3  4.8  10.0  2.4  8.4 
  ≥4  10.7  3.9  13.4  11.3  2.7  10.0  10.3  5.1  17.6 
P for trend (ANCOVA)    <0.001      0.01      <0.001     
1

Differences between consumption categories are expressed as percentage of the reference category and as percentage of the standard deviation (SD) of the dependent variable.

2

Estimated marginal means.

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Table 3.

Coffee consumption and plasma tHcy concentrations.1

Coffee, cups/day All Men Women
Plasma concentration2 Difference Plasma concentration2 Difference Plasma concentration2 Difference
% % of SD % % of SD % % of SD
tHcy, μmol/L  0  10.1  Ref  Ref  10.7  Ref  Ref  9.5  Ref  Ref 
  1–3  10.4  3.5  12.0  11.0  2.5  9.3  9.9  4.5  15.5 
  ≥4  10.8  6.8  23.3  11.2  5.1  18.6  10.3  8.8  29.5 
P for trend (ANCOVA)    <0.001      <0.001      <0.001     
tHcy after adjustment for folate, μmol/L  0  10.3  Ref  Ref  10.9  Ref  Ref  9.8  Ref  Ref 
  1–3  10.5  1.8  6.4  11.0  1.3  4.8  10.0  2.4  8.4 
  ≥4  10.7  3.9  13.4  11.3  2.7  10.0  10.3  5.1  17.6 
P for trend (ANCOVA)    <0.001      0.01      <0.001     
Coffee, cups/day All Men Women
Plasma concentration2 Difference Plasma concentration2 Difference Plasma concentration2 Difference
% % of SD % % of SD % % of SD
tHcy, μmol/L  0  10.1  Ref  Ref  10.7  Ref  Ref  9.5  Ref  Ref 
  1–3  10.4  3.5  12.0  11.0  2.5  9.3  9.9  4.5  15.5 
  ≥4  10.8  6.8  23.3  11.2  5.1  18.6  10.3  8.8  29.5 
P for trend (ANCOVA)    <0.001      <0.001      <0.001     
tHcy after adjustment for folate, μmol/L  0  10.3  Ref  Ref  10.9  Ref  Ref  9.8  Ref  Ref 
  1–3  10.5  1.8  6.4  11.0  1.3  4.8  10.0  2.4  8.4 
  ≥4  10.7  3.9  13.4  11.3  2.7  10.0  10.3  5.1  17.6 
P for trend (ANCOVA)    <0.001      0.01      <0.001     
1

Differences between consumption categories are expressed as percentage of the reference category and as percentage of the standard deviation (SD) of the dependent variable.

2

Estimated marginal means.

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